All Melanoma News

Innovative research has unveiled promising advancements in melanoma detection, which could significantly enhance diagnosis and prognosis by identifying the disease at its earliest, most treatable stages.

THURSDAY, Sept. 26, 2024 (HealthDay News) — Patients with primary thyroid cancer who receive radioactive iodine therapy have an elevated risk for melanoma and other nonkeratinocyte skin cancers when limiting the cancer site to the head and neck, according to a study published online Sept. 19 in JAMA Network Open.

Meredith McKean, MD, executive committee chair, Melanoma and Skin Cancer Research Program, executive committee chair, BRIDGE Program, Sarah Cannon Research Institute, discusses the rationale for combining fianlimab with cemiplimab-rwlc (Libtayo) in the treatment of patients with advanced melanoma and highlights long-term follow-up data with the combination. Notably, these phase 1 trial (NCT03005782) data were shared at the 2024 ESMO Congress.

Major Finding: Age-associated changes in male fibroblasts induce a phenotypic switch to invasive and resistant melanoma.

TH17 cells may be a potential biomarker to predict the risk of immune-related adverse events in patients with metastatic melanoma receiving the combination therapy of nivolumab, ipilimumab, and tocilizumab.

Ten-year follow up from the CheckMate 067 and KEYNOTE-006 trials confirm that patients with advanced melanoma can achieve durable responses from treatment with the PD1 inhibitors nivolumab and pembrolizumab and that a lack of disease progression at 3 years is strong indicator of long-term survival.

Patients with advanced melanoma reach a plateau in survival after treatment with immune checkpoint inhibitors (ICIs), according to real-world data published in JAMA Network Open.

As Australian patients begin to spend more time in the sun, the Royal Australian College of GPs (RACGP) has urged patients to organise a skin check with their GP to ensure dangerous skin cancers are detected and treated early.

Swedish medical detection company SciBase Holding has seen its artificial intelligence (AI) powered device for detecting melanomas, dubbed Nevisense, validated as part of a consensus report that found it effective in detecting potential cancers.

Health-related quality of life among patients with stage 3 melanoma was not significantly affected after receiving postsurgical Keytruda or placebo.

Drug therapies for the treatment of melanoma are advancing, and many now play a role for the treatment of earlier stage disease, according to new research.

A new algorithm has found that combining immune checkpoint inhibitors bolsters immune response among some patients with advanced melanoma.

ROCHESTER, Minn. — About 8 to 10 million Americans over age 40 have an overabundance of cloned white blood cells, or lymphocytes, that hamper their immune systems. Although many who have this condition — called monoclonal B-cell lymphocytosis (MBL) — do not experience any symptoms, a new study shows they may have an elevated risk for several health complications, including melanoma, a form of skin cancer. The findings, by Mayo Clinic researchers, are published in a new paper in the Journal of Clinical Oncology.

PHILADELPHIA (September 6, 2024) — In a study published today in the prestigious journal Cell, researchers from Fox Chase Cancer Center and Johns Hopkins Kimmel Cancer Center showed changes that occur with age in male skin fibroblasts contributed to an increase in the spread of melanoma cells and made cancer cells resistant to targeted therapy.

IBI363 has earned fast track designation from the FDA for the treatment of previously treated unresectable advanced melanoma.

The results of newly reported research in human cells and in mice, carried out by scientists at Johns Hopkins Kimmel Cancer Center, suggest that age-related changes in fibroblasts contribute to the development of aggressive, treatment-resistant melanoma in males. The researchers, co-led by Ashani Weeraratna, PhD, the Bloomberg Distinguished Professor, E.V. McCollum Professor, and chair of the department of biochemistry and molecular biology at Johns Hopkins, found that human skin fibroblasts—cells that create the skin’s structure—show age-and sex-specific changes in proliferation and stress response, and that male fibroblasts age faster due to elevated levels of reactive oxygen species (ROS).

Excision with 5-mm margins for melanoma in situ that is less than 10 mm in size on low-risk body sites is associated with a low recurrence rate, according to a study published in JAMA Dermatology.

WEDNESDAY, Sept. 11, 2024 (HealthDay News) — Ultraviolet (UV) exposure remains associated with an increased risk for melanoma in patients with Fitzpatrick skin types I to IV, according to a systematic review and meta-analysis published online Sept. 4 in the Journal of the European Academy of Dermatology and Venereology.

Melanoma is the 17th most common cancer in the world, with over 300,000 patients diagnosed worldwide in 2022 alone.

Melanoma is a malignant type of skin cancer and is the fifth most common type of cancer in the United States.

From the RELATIVITY-047 (NCT03470922) and CheckMate 067 (NCT01844505) trials, what are the most important efficacy and safety data?

Melanoma rates differ consistently between men and women in terms of the ages at which melanomas occur and the locations on the body where they occur.

Appetite change, tiredness, lymph node enlargement, abdominal pain and shortness of breath were common with melanoma recurrence.

The standard of care for resectable stage IIIB or greater melanoma has been neoadjuvant therapy, and new data shows that neoadjuvant immunotherapy provides a long-lasting benefit to these patients, particularly if they achieve a major pathological response (MPR), which is a complete response or a near complete pathological response.

Ahmad Tarhini, MD, PhD, director, Cutaneous Clinical and Translational Research, leader, Neoadjuvant and Adjuvant Translational Science Program, senior member, Moffitt Cancer Center, Research Institute Departments of Cutaneous Oncology and Immunology; professor, Oncologic Sciences, the University of South Florida Morsani College of Medicine; chair, Scientific Committee, Oncology Research Information Exchange Network (ORIEN); chair, ORIEN ImmunoOncology Research Subcommittee, discusses the rationale for investigating high-dose bolus interleukin-2 (IL-2) plus concurrent low-dose ipilimumab (Yervoy), followed sequentially by nivolumab (Opdivo), in patients with advanced melanoma.

Adverse effects from immunotherapy treatment in melanoma patients are associated with a distinct pattern of
gene expression, offering the possibility for improved therapeutic strategies.

For patients with a high burden of non-melanoma cancers, there is more to prevention than just sun avoidance and regular checks and excisions.

Adjuvant pembrolizumab did not have a significant impact on long-term HRQOL outcomes in patients with resected stage III melanoma.

Polygenic risk scores (PRS) may serve as a viable tool to stratify patients based on their risk of invasive melanoma, according to a study published in JAMA Dermatology.

Toni English’s medical team was giddy.

For patients diagnosed with uveal melanoma, what is the prognosis and the risk of recurrence?

Experts discuss unmet needs and challenges faced by patients with uveal melanoma. This program was made possible with support from Immunocore.

In this study, the investigators retrospectively analyzed the incidence of metastasis in 8,034 patients with uveal melanoma over a 35-year period based on tumor size category.

A new research paper was published in Oncotarget entitled, “Prognostic and therapeutic insights into MIF, DDT, and CD74 in melanoma."

About 8 to 10 million Americans over age 40 have an overabundance of cloned white blood cells, or lymphocytes, that hamper their immune systems. Although many who have this condition — called monoclonal B-cell lymphocytosis (MBL) — do not experience any symptoms, a new study shows they may have an elevated risk for several health complications, including melanoma, a form of skin cancer. The findings, by Mayo Clinic researchers, are published in a new paper in the Journal of Clinical Oncology.

The risk of skin cancer, malignant melanoma, now appears to be decreasing in Sweden—at least in those under 50, according to a new study.

Researchers tailored screening and surveillance schedules to individual risk of patients.

Microbiotica has received the green light from EU and UK regulatory authorities to start phase 1b studies for its microbiome medicines in advanced melanoma and ulcerative colitis.

During a Case-Based Roundtable® event, Hussein A. Tawbi, MD, PhD, and participants considered nivolumab/ipilimumab and nivolumab/relatlimab as options for a patient with metastatic melanoma in the first article of a 2-part series.

Updated findings from the phase 2/3 RELATIVITY-047 trial (NCT03470922) showing sustained responses and favorable survival outcomes with nivolumab (Opdivo) plus relatlimab-rmbw (Opdualag) in previously untreated patients with metastatic or unresectable melanoma signal the diminishing role for anti–PD-1 monotherapy in the frontline setting, according to Ankit Mangla, MD.

PHILADELPHIA – A new tool for monitoring immune health patterns over time has revealed how a pair of checkpoint inhibitor therapies works together to recruit new cancer-fighting T cells with every infusion. Findings from the use of the new tool, developed by researchers at the University of Pennsylvania Perelman School of Medicine and Penn Medicine’s Abramson Cancer Center (ACC), were published today in Cancer Cell. The study challenges fundamental assumptions about how a common immunotherapy drug combination activates different types of T cells to defeat cancer and could help researchers more precisely measure immune response in future clinical trials.

Treatment induced sustained T-cell responses among patients with melanoma and non-small cell lung cancer.

A retrospective cohort study by Yale Cancer Center researchers of nearly 200 patients with melanoma who died after receiving treatment with immunotherapy highlights a need to improve outcomes for patients after the treatment.

In an analysis from the phase III EORTC 1325-MG/KEYNOTE-054 trial reported in The Lancet Oncology, Bührer et al found that adjuvant pembrolizumab was not associated with significant differences in long-term health-related quality of life (HRQOL) compared with placebo in patients with stage III melanoma.

Allison Betof Warner, MD, PhD, and the Oncology Brothers share clinical insights on treatment decisions for patients with metastatic melanoma.

An activity pattern in certain genes responsible for building proteins known as spleen tyrosine kinases can predict which melanoma patients are likely to have severe side effects from immunotherapy designed to treat the most deadly skin cancer, a new study shows.

A new research paper titled “Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival" has been published in Oncotarget.

The cancer vaccine, mRNA-4157, garnered immune responses of 30 weeks among some patients with melanoma and lung cancer, study results showed.

For decades, researchers have worked to develop therapies that can prime the immune system to recognize and attack proteins on the surface of tumor cells.

Medical oncologists provide comprehensive insights on neoadjuvant therapy options for patients with melanoma.

Hispanic men with cutaneous melanoma receive melanoma diagnoses at an older age, show advanced-stage disease, present with melanoma of the trunk rather than lower extremities, and have reduced disease-specific survival when compared with Hispanic women with melanoma, according to study results published in Skin Health and Disease.

BUFFALO, NY- August 8, 2024 – A new research paper was published in Oncotarget’s Volume 15 on August 5, 2024, entitled, “Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival.”

Scientists at NYU Langone Health and its Perlmutter Cancer Center have revealed that an activity pattern in genes that build spleen tyrosine kinases can predict which melanoma patients are likely to have severe side effects from immunotherapy.

An activity pattern in certain genes responsible for building proteins known as spleen tyrosine kinases may predict the occurrence of severe side effects from immunotherapy in patients with melanoma, according to a recent study published by Monson et al in Clinical Cancer Research.

The spleen tyrosine kinase pathway was upregulated in patients that had severe toxicities from immune checkpoint inhibitor therapy.

A new research paper was published in Oncotarget’s Volume 15 on August 5, 2024, entitled, “Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival."

Drs Armstrong and Tawagi discuss the NADINA trial of neoadjuvant nivolumab/ipilimumab vs adjuvant nivolumab in resectable, macroscopic, stage III melanoma.

In an analysis from the phase III CheckMate 238 trial reported in the Journal of Clinical Oncology, Jeffrey Weber, MD, PhD, and colleagues found that progression-free and overall survival were improved with subsequent systemic therapy following late vs early recurrence with adjuvant nivolumab in patients with resected stage IIIB–C or IV melanoma.

A sNDA seeking the approval of toripalimab for frontline use in patients with unresectable or metastatic melanoma is under review by the NMPA.

Two studies published in the latest issue of the journal Cell by University of Pittsburgh researchers uncover how immunotherapies targeting the immune checkpoints PD1 and LAG3 work together to activate immune responses.

Georgina V. Long, MBBS, PhD, FRACP, co-medical director, Melanoma Institute Australia (MIA), and chair, Melanoma Medical Oncology and Translational Research, MIA and Royal North Shore Hospital, The University of Sydney, discusses the remaining unmet needs for patients with BRAF-mutant melanoma and how data from the phase 3 NADINA trial (NCT04949113) could help address some of these needs.

The conventional treatment paradigms for melanoma and non–small cell lung cancer (NSCLC) have historically centered around surgery, radiation, and chemotherapy.

New studies have uncovered how immunotherapies targeting the immune checkpoints PD1 and LAG3 work in concert to active immune responses and may improve outcomes in patients with melanoma compared with monotherapies targeting only PD1.

Ahmad Tarhini, MD, PhD, director, Cutaneous Clinical and Translational Research, leader, Neoadjuvant and Adjuvant Translational Science Program, senior member, Moffitt Cancer Center, Research Institute Departments of Cutaneous Oncology and Immunology; professor, Oncologic Sciences, University of South Florida Morsani College of Medicine; chair, Scientific Committee, Oncology Research Information Exchange Network (ORIEN); chair, ORIEN ImmunoOncology Research Subcommittee, discusses the use of high-dose bolus interleukin-2 (IL-2) with concurrent low-dose ipilimumab (Yervoy), followed sequentially by nivolumab (Opdivo), in patients with advanced melanoma.

Time magazine and Time for Kids has chosen its 2024 Kid of the Year — and it’s Heman Bekele, a teenager who could change the way skin cancer is treated.

Michelle Bolas and Rukiyah T. Van Dross-Anderson, PhD, discuss the significance of NCInnovations’ funding and the clinical impact of Van Dross-Anderson’s research in patients with advanced melanoma.

Melanomas that develop from giant pigmented nevi are diagnosed in younger patients more commonly than other melanomas; and while more these are more aggressive in patients younger than 10 years of age, they are mostly localized at the time of diagnosis, according to study results published in the Journal of the American Academy of Dermatology.

A study explored a new approach to treating melanoma that has spread to the meninges, the membranes surrounding the brain and spinal cord (leptomeningeal disease or LMD).

Citing toxicities and lack of efficacy, some are calling for caution when treating older patients with melanoma with immune checkpoint inhibitors.

Paolo Ascierto, MD, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Naples, Italy, discusses primary results from the phase 2 NEO-TIM trial which sought to determine the optimal sequencing of vemurafenib, cobimetinib, and atezolizumab among patients with patients with high-risk melanoma.

Researchers have found that among patients with certain melanoma, presurgical targeted therapy and immunotherapy can result in better pathologic response.

Imagine tiny fists punching their way through your body.

Uveal melanoma is a rare cancer type with an incidence of 7.6 per million adults in Australia and represents around 5% of all melanomas.

Researchers use molecular imaging to uncover the genetic factors that drive this aggressive skin cancer

OBX-115 is a novel engineered tumor infiltrating lymphocyte (TIL) therapy designed to treat patients with checkpoint inhibitor-resistant metastatic melanoma.

The addition of RNA expression of the cancer-testis antigen PRAME (preferentially expressed antigen in melanoma) to a 15-gene expression profile (15-GEP) offered significantly improved and more precise prognostic information over the 15-GEP alone.

Vanderbilt researchers have developed a set of nanoparticles that stimulate the immune system in mice to fight cancer and may eventually do the same in humans.

A new research paper was published in Oncotarget entitled, “Prognostic and therapeutic insights into MIF, DDT, and CD74 in melanoma."

A few studies have highlighted the differences between healthcare professionals with CVD and those with normal color vision.

Tumor-infiltrating lymphocyte (TIL) therapy in combination with high-dose interleukin-2 (IL-2) should be considered as a second-line treatment of choice for patients with advanced melanoma who have received anti-PD-(L)1 therapy, according to researchers.

BioNTech has announced positive topline findings from an ongoing phase 2 trial (NCT04526899) evaluating the investigational mRNA cancer immunotherapy BNT111 in combination with cemiplimab (Libtayo) for patients with unresectable stage III or IV melanoma who experienced disease progression following anti-PD-(L)1 therapy.

An immunotherapy combination improved outcomes compared with historical control for certain patients with advanced melanoma, according to a topline data announcement.

WEDNESDAY, July 31, 2024 (HealthDay News) — Site-specific melanoma incidence trends may be partially related to genetic risk, according to a study published online July 19 in the British Journal of Dermatology.

Integrating 15-GEP with PRAME expression status into a 4-group prognostic classification system showed prognostic accuracy in uveal melanoma.

Cong Peng et al., at Department of Dermatology, Xiangya Hospital, Central South University, China, conducted a study titled “NETO2 promotes melanoma progression via activation of the Ca²?/CaMKII signaling pathway" that investigates the role of Neuropilin and tolloid-like 2 (NETO2) in melanoma, a deadly form of skin cancer.

Excision with 5-mm margins for melanoma in situ that is less than 10 mm in size on low-risk body sites is associated with a low recurrence rate, according to a study published in JAMA Dermatology.

Cong Peng and others at the Department of Dermatology, Xiangya Hospital, Central South University, China, conducted a study titled “NETO2 promotes melanoma progression via activation of the Ca2+/CaMKII signaling pathway," which investigated the role of Neuropilin and tolloid-like 2 (NETO2) in melanoma, a deadly form of skin cancer.

Allison Betof Warner, MD, PhD, joins Rahul Gosain, MD, and Rohit Gosain, MD, to discuss treatment practices for patients with stage IIB and beyond melanoma.

Georgina V. Long, MD, PhD, of the Melanoma Institute Australia and the University of Sydney, and colleagues reported the final follow-up analysis of the phase III COMBI-AD trial at the 2024 ASCO Annual Meeting (Abstract 9500) and published their findings in The New England Journal of Medicine.

Yu-Hwa Huang, Ph.D. and Charles Yoon, MD, of the Department of Medicine and Department of Surgery at Brigham and Women’s Hospital respectively, are co-lead authors of a paper titled “High-dimensional mapping of human CEACAM1 expression on immune cells and association with melanoma drug resistance," published in Communications Medicine. In this article, they discuss their findings.

Melanoma, a deadly form of skin cancer, poses a significant global health concern.

ROTTERDAM, Netherlands and SAN DIEGO, July 9, 2024 /PRNewswire/ — SkylineDx, an innovative diagnostics company specializing in the research and development of molecular diagnostics for oncology, inflammatory, and infectious diseases, proudly announces the successful enrollment of the MERLIN_001 study.

The Food and Drug Administration (FDA) has granted Fast Track designation to OBX-115 for the treatment of metastatic, or locally advanced melanoma that is refractory to, or has relapsed after programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1)–based immune checkpoint inhibitors (ICI).

In September 2023, a new feature was added to ChatGPT (OpenAI) that allows the analysis of images, including those obtained through dermatoscopy.

Melanoma was the topic of some of the most exciting abstracts at this year’s American Society of Clinical Oncology (ASCO) Annual Meeting.

Rosacea patients have more than five times the risk of developing a malignant melanoma and a greater risk of several other systemic conditions, according to researchers.

Sun C, Lim A, De’Ambrosis B, et al. Recurrence Rate of Small Melanoma in Situ on Low-Risk Sites Excised With 5-mm Excisional Margin. JAMA Dermatol (2024).

(Vienna, 16 July 2024) Targeted therapies are a powerful weapon against skin cancer, but their side effects can severely impact a patient’s quality of life.

NADINA trial results support a new standard of care for these patients.

An exciting biologic drug called brenetafusp is being studied, and showing real promise, in treating advanced cutaneous melanoma.

For those living with advanced melanoma, brain metastases— malignant growths that occur when cancer cells travel to the brain—are particularly challenging to treat.

Nikhil Khushalani, MD, vice chair, Department of Cutaneous Oncology, Moffitt Cancer Center, discusses the benefits and limitations of fixed-dose treatment regimens, such as the combination of fianlimab (formerly REGN 3767) and cemiplimab-rwlc (Libtayo) that is under investigation in the phase 3 HARMONY HEAD TO HEAD trial (NCT06246916) in patients with unresectable or metastatic melanoma.

In patients with resected stage III melanoma, adjuvant therapy with dabrafenib plus trametinib reduces the risk for death by 20% compared with placebo, though the overall survival benefit does not reach statistical significance.

Australians are unable to recognize malignant melanomas on their own skin, calling into question the effectiveness of national self-detection guidelines, according to new Southern Cross University research.

A new cancer vaccine targeting melanoma, currently the subject of a phase 2 trial, has shown “promising” results, as one researcher tells CURE®.

In a phase I trial reported in the Journal of Clinical Oncology, Omid Hamid, MD, and colleagues found that the combination of the human lymphocyte activation gene-3 (LAG-3)-targeting monoclonal antibody fianlimab plus the PD-1–targeting monoclonal antibody cemiplimab-rwlc was active in patients with advanced melanoma.

In February 2021, a pair of remarkable clinical trials was published1,2. Each one involved people with melanoma. Some participants had been successfully treated using drugs called immune checkpoint inhibitors, which help the body to destroy cancer cells. The others had failed to respond to the treatment.

Patients with rosacea have an increased risk for malignant melanoma, joint problems, metabolic disease and visual disturbances, according to a study.

Among people diagnosed with cutaneous melanoma in the United States, those who live in rural areas have significantly lower rates of survival than those who live in urban areas, results from an analysis of data from the National Cancer Institute showed.

Milwaukee — Today, the Froedtert & MCW Cancer Network announced it will begin to offer new treatment to patients with advanced melanoma. Lifileucel, created by Iovance, is the first cell therapy treatment to be FDA approved for the deadliest form of skin cancer.

Neoadjuvant immunotherapy given for stage III melanoma, followed by adjuvant therapy only if there is not a deep response to treatment, promises better outcomes for patients than the current standard of care, which is adjuvant immunotherapy alone.

Mektovi (binimetinib) is a prescription drug that’s used to treat certain types of cancer. Mektovi can cause side effects that range from mild to serious. Examples include nausea, diarrhea, and vomiting.

UC San Diego Health is the first hospital system in the region to offer a new immunotherapy treatment for metastatic melanoma. The personalized cellular therapy derived from tumor infiltrating lymphocytes (TIL), is the first solid tumor therapy on the market approved by the U.S. Food and Drug Administration (FDA).

The oncolytic immunotherapy RP1 in combination with nivolumab (Opdivo) displayed activity in patients with melanoma who failed prior anti–PD-1 treatment, according to updated findings from the phase 2 IGNYTE trial (NCT03767348).

An international research team led by scientists from the University of Liège has discovered an interesting new therapeutic target for the treatment of melanoma resistant to targeted therapies.

Investigators examined 100 metastases and developed a Uveal Melanoma Immunogenomic Score to predict which patients will respond to immunotherapy.

Immunotherapy is an effective yet very expensive treatment for melanoma.

Investigators may have uncovered sex-based disparities in the detection and survival of melanoma in Black patients, according to a recent study published by Steadman et al in the Journal of Surgical Oncology.

Researchers say addressing socioeconomic differences may be the key to addressing this disparity.

PARTICIPANT LIST Raymond Lobins, DO | David Potter, MD | Mark Karwal, MD | Shahid Waheed, MD | Somasekhara R. Bandi, MD | Christiane Zoghbi, MD | Hilary Ufearo, MBBS

If melanoma spreads, there are various therapies that can be used. However, there is still insufficient research into who responds to which therapy and whether resistance may develop over time.

During a Case-Based Roundtable® event, Evan J. Lipson, MD, discussed with participants whether factors such as patient preference influence their choice of melanoma treatment in the second article of a 2-part series.

Jose Lutzky, MD, discussed the promise of tumor infiltrating lymphocyte therapy for difficult-to-treat advanced melanoma.

Click here to read more and answer our quiz questions in recognition of Skin Cancer Awareness Month.

Earlier this week, we shared our third Skin Cancer Awareness Month quiz. Review the answers and your responses below.

In recognition of Skin Cancer Awareness Month, Dermatology Times is reviewing research and strides in skin cancer treatment over the last decade.

When it comes to skin cancer, most people think of warnings about sunburn and tanning beds.

Andrew Baker, MBA, MPAS, PA-C, discusses his role in skin cancer detection and advice for PAs interested in skin surgeries and Mohs closures.

The personalized cancer vaccine research paradigm is expanding, with particular advancements occurring in patients with high-risk melanoma, in whom vaccines have been shown to induce and strengthen responses to immunotherapy, according to Patrick Ott, MD, PhD.

A person’s genetics play a more prominent role in melanoma than previously believed, according to a study published in the Journal of the American Academy of Dermatology.

TIL (tumor-infiltrating lymphocyte) therapy is a promising new approach for treating advanced melanoma. It leverages the power of a patient’s own immune system to combat cancer cells.

An artificial intelligence-based smartphone app used by primary care physicians showed high diagnostic accuracy in detecting cutaneous melanoma.

On the left melanoma cells (in green) can be seen surviving in the presence of cytotoxic lymphocytes (red), when they express one of these immunosuppressive proteins.

While checkpoint inhibitors are a mainstay in the field of advanced melanoma treatment, novel and reimagined therapies offer new hope for this challenging disease state.

A new study found proprotein convertase subtilisin/kexin type 9 (PCSK9) is associated with an increased cutaneous melanoma risk.

Almost two-thirds of patients diagnosed with metastatic melanoma are expected to die within five years, but a newly approved treatment may help some patients live longer.

Age-related changes to the skin’s elasticity may drive higher rates of metastatic skin cancer among older individuals, according to study results.

A recent study shows that there may be a more effective way to treat melanoma by using ascorbate (vitamin C) to increase DNA damage in cancer cells, leading to their death, according to co-corresponding author of the study Marcus Cooke, professor and chair in the Department of Molecular Biosciences.

ROTTERDAM, Netherlands, and SAN DIEGO, May 30, 2024 /PRNewswire/ — SkylineDx announces the presentation of groundbreaking data at the American Society of Clinical Oncology (ASCO) 2024 Annual Meeting.

Immunotherapy is an effective yet very expensive treatment for melanoma.

Investigators may have uncovered sex-based disparities in the detection and survival of melanoma in Black patients, according to a recent study published by Steadman et al in the Journal of Surgical Oncology.

Researchers say addressing socioeconomic differences may be the key to addressing this disparity.

During a Case-Based Roundtable® event, Michael B. Atkins, MD, discussed the choice of therapy for a 78-year-old patient with metastatic melanoma with participants.

If melanoma spreads, there are various therapies that can be used. However, there is still insufficient research into who responds to which therapy and whether resistance may develop over time.

During a Case-Based Roundtable® event, Evan J. Lipson, MD, discussed with participants whether factors such as patient preference influence their choice of melanoma treatment in the second article of a 2-part series.

Jose Lutzky, MD, discussed the promise of tumor infiltrating lymphocyte therapy for difficult-to-treat advanced melanoma.

Click here to read more and answer our quiz questions in recognition of Skin Cancer Awareness Month.

Earlier this week, we shared our third Skin Cancer Awareness Month quiz. Review the answers and your responses below.

In recognition of Skin Cancer Awareness Month, Dermatology Times is reviewing research and strides in skin cancer treatment over the last decade.

When it comes to skin cancer, most people think of warnings about sunburn and tanning beds. Thoughts of “cancer genes" or inherited risks are reserved for diseases like breast cancer or colon cancer. A new study challenges this status quo by showing that genetics play a larger role in melanoma risk than recognized.

Andrew Baker, MBA, MPAS, PA-C, discusses his role in skin cancer detection and advice for PAs interested in skin surgeries and Mohs closures.

The personalized cancer vaccine research paradigm is expanding, with particular advancements occurring in patients with high-risk melanoma, in whom vaccines have been shown to induce and strengthen responses to immunotherapy, according to Patrick Ott, MD, PhD.

A person’s genetics play a more prominent role in melanoma than previously believed, according to a study published in the Journal of the American Academy of Dermatology.

TIL (tumor-infiltrating lymphocyte) therapy is a promising new approach for treating advanced melanoma. It leverages the power of a patient’s own immune system to combat cancer cells.

An artificial intelligence-based smartphone app used by primary care physicians showed high diagnostic accuracy in detecting cutaneous melanoma.

By investigating the origin and evolution of melanoma, several groups at the Spanish National Cancer Research Center (CNIO), who are international leaders in the field, have come up with promising strategies.

While checkpoint inhibitors are a mainstay in the field of advanced melanoma treatment, novel and reimagined therapies offer new hope for this challenging disease state. These therapies include using older agents like interluekin-2 (IL-2) or tumor-infiltrating lymphocytes (TILs) and modifying them to make their activity more potent against melanoma. Additionally, oncolytic vaccines administered into the tumor or systemically can help to sensitize the immune system and improve the response to checkpoint inhibitors.

A new study found a greater PCSK9 is associated with a greater cutaneous melanoma risk.

Age-related changes to the skin’s elasticity may drive higher rates of metastatic skin cancer among older individuals, according to study results.

A recent study shows that there may be a more effective way to treat melanoma by using ascorbate (vitamin C) to increase DNA damage in cancer cells, leading to their death, according to co-corresponding author of the study Marcus Cooke, professor and chair in the Department of Molecular Biosciences.

ROTTERDAM, Netherlands, and SAN DIEGO, May 30, 2024 /PRNewswire/ — SkylineDx announces the presentation of groundbreaking data at the American Society of Clinical Oncology (ASCO) 2024 Annual Meeting.

Daniel Olson, MD, assistant professor, medicine, the University of Chicago Medical Center, UChicago Medicine, discusses the benefit associated with lifileucel (Amtagvi) in patients with unresectable or metastatic melanoma, highlighting patients likely to derive the most benefit from this treatment approach.

Results of a systematic review provide insights that may help guide surveillance in patients with melanoma, but the results also suggest more data are needed to identify optimal surveillance strategies, according to researchers. The researchers shared their findings in Surgical Oncology.

Vishal Patel, MD, FAAD, FACMS, associate professor, Dermatology, George Washington (GW) School of Medicine & Health Sciences; director, Cutaneous Oncology Program, GW Cancer Center, discusses the evolving use of PD-1 inhibitors for patients with cutaneous squamous cell carcinoma (CSCC) in the neoadjuvant and adjuvant setting.

Desai emphasized that most dermatologists would rather biopsy a potential melanoma than miss one that could become deadly.

During a Case-Based Roundtable® event, Evan J. Lipson, MD, discussed with participants how their experience with immunotherapy toxicities has changed over time in the first article of a 2-part series.

Intravenous infusion with OBX-115, an IL-2–free, regulatable, engineered tumor-infiltrating lymphocyte (TIL) cell therapy was well tolerated and produced durable antitumor responses in patients with immune checkpoint inhibitor (ICI)-resistant advanced melanoma, according to data from a first-in-human, single-center, phase 1 study (NCT05470283) presented at the 2024 AACR Annual Meeting.

A retrospective analysis out of Denmark could not find a causal relationship to explain trends in melanoma incidence and mortality rates, demonstrating the need for more research in this area.

Although dual suppression of the mTOR and MAPK pathways could be a viable therapy avenue for patients with pretreated advanced melanoma, overcoming overlapping toxicities when combining these types of therapies will be paramount, according to Zeynep Eroglu, MD.

Despite an increasing prevalence of cutaneous malignant melanoma (CMM) worldwide, CMM-associated mortality has decreased in recent years, according to study results published in Melanoma Research.

The study aimed to improve the understanding of lived experiences and the fear of recurrence among survivors of localized, stage 0 to IIA cutaneous melanoma.

Zeynep Eroglu, MD, medical oncologist, Department of Cutaneous Oncology, Moffitt Cancer Center; assistant professor, Department of Oncologic Sciences, the University of South Florida Morsani College of Medicine, discusses unmet needs that currently exist for patients with mutant melanoma, highlighting a phase 1/2 trial (NCT03501368) that evaluated ceritinib (Zykadia) alone and in combination with trametinib (Mekinist) for these patients.

Immunogenomic factors were found to be predictive of resistance to immunotherapy and to tumor susceptibility to the therapeutic class in patients with metastatic uveal melanoma, according to findings from a study published in Nature Communications.

A multipeptide vaccine combination approach with 12MP plus 6MHP vs 12MP plus tet extended overall survival in patients with stage IIB to IV melanoma.

Encorafenib, given with or without binimetinib, provides long-term benefits for patients with BRAF V600E/K-mutant advanced melanoma, according to results from the phase 3 COLUMBUS trial published in the European Journal of Cancer.

Our May issue of Dermatology Times spotlights melanoma/skin cancer awareness and more.

Alpha-9 Oncology has dosed the first participant in its study evaluating Ga-A9-3202 for the imaging of melanoma.

Some of the final work of a late University of Virginia School of Medicine scientist has opened the door for life-saving new treatments for solid cancer tumors, including breast cancer, lung cancer and melanoma.

From 1999 to 2019, the incidence of invasive melanoma cases increased by 2.5-fold.

In a study reported in The Lancet Oncology, Stassen et al developed a model for the prediction of recurrence-free and melanoma-specific survival after sentinel lymph node biopsy (SLNB) in patients with melanoma.

A cross-sectional, mixed-methods study found that adverse effects (AEs) can occur even after 1 year of treatment with immune checkpoint modulator (ICM) therapy in patients with melanoma.

NEW YORK – Spatial biology company Akoya Biosciences and German prognostic test developer NeraCare said Thursday that they have inked an exclusive agreement to develop assays for skin cancer.

An international study led by Dr. Li Qi-Jing from the Agency for Science, Technology and Research (A*STAR) has revealed a mechanism by which melanoma, the most aggressive form of skin cancer, evades the immune system.

ROCHESTER, Minn. — Melanoma, an aggressive form of skin cancer that accounts for 75% of all skin-cancer-related deaths, is often detected later in people with darker skin complexions — and the consequences can be devastating, a Mayo Clinic study reveals.

Researchers found that the diameter of cutaneous melanoma demonstrated a weak positive correlation with tumor thickness.

Researchers may have uncovered the mechanisms behind the development of targeted therapy resistance in melanoma, according to a recent study published by Aya Moreno et al in Cell Reports.

Researchers at the Centre for Genomic Regulation (CRG) have discovered one of the mechanisms through which melanoma drug resistance occurs.

Michael Farwell, MD, associate professor of radiology at the Hospital of the University of Pennsylvania, provides insights into a study on the benefits of using 18F-fluorodeoxyglucose (FDG) PET/CT imaging to detect metabolic tumor changes in skin cancer.

Omid Hamid, MD, director, Melanoma Program, Cedars-Sinai Medical Center, chief, Translational Research and Immunotherapy, director, Melanoma Therapeutics, Phase I Immuno-Oncology Program, The Angeles Clinic and Research Institute, discusses the use of lifileucel (Amtagvi) in the treatment of patients with advanced melanoma.

New research from the University of Pittsburgh explains why metastatic uveal melanoma is resistant to conventional immunotherapies and how adoptive therapy, which involves growing a patient’s T cells outside the body before reinfusing them, can successfully treat this rare and aggressive cancer.

A survey of oncologists and review of patient data revealed factors driving decisions about adjuvant therapy for patients with stage III melanoma.

New research from the University of Pittsburgh explains why metastatic uveal melanoma is resistant to conventional immunotherapies and how adoptive therapy, which involves growing a patient’s T cells outside the body before reinfusing them, can successfully treat this rare and aggressive cancer.

Researchers may have uncovered the mechanisms behind conventional immunotherapy resistance as well as the efficacy of adoptive therapy in metastatic uveal melanoma, according to a recent study published by Leonard-Murali et al in Nature Communications. The findings demonstrated the potential to improve personalized therapies and avoid unnecessary treatments in metastatic uveal melanoma.

Scientists have discovered how skin cancer cells shapeshift based on their environment – enabling them to spread through the body and cause a metastatic cancer.

Daniel Olson, MD, assistant professor, medicine, the University of Chicago Medical Center, UChicago Medicine, discusses toxicities associated with lifileucel (Amtagvi) and interleukin-2 (IL-2)in patients with unresectable or metastatic melanoma.

John M. Kirkwood, MD, Distinguished Service Professor of Medicine, Sandra and Thomas Usher Professor of Medicine, Dermatology & Translational Science, coleader, Melanoma and Skin Cancer Program, Division of Hematology/Oncology, the University of Pittsburgh, discusses the significance of the FDA approval of adjuvant nivolumab (Opdivo) for patients with resected stage IIB or IIC melanoma.

Hello. I’m Dr Jeffrey Weber. I’m a medical oncologist at the Laura and Isaac Perlmutter Cancer Center in New York City at NYU Langone Health.

Omid Hamid, MD, professor, medicine, Cedars-Sinai; director, Clinical Research and Immunotherapy, director, Cutaneous Oncology and Melanoma, The Angeles Clinic and Research Institute, discusses how the tumor-infiltrating lymphocyte (TIL) lifileucel (Amtagvi) may address historical unmet needs in relapsed melanoma.

Daniel Olson, MD, assistant professor, medicine, the University of Chicago Medical Center, UChicago Medicine, discusses the benefit associated with lifileucel (Amtagvi) in patients with unresectable or metastatic melanoma, highlighting patients likely to derive the most benefit from this treatment approach.

It is unclear why the vaccines were less effective in women, but researchers note that the findings can be important when determining immune therapy outcomes in patients with melanoma.

Despite a high frequency of atypical features, longitudinal melanonychia (LM) in children is associated with an exceedingly low rate of malignancy.

Jonathan Zager, MD, spoke about the use of observation vs systemic immunotherapy to treat patients with stage IIIA and IIIB melanoma.

In a study reported in The Lancet Oncology, Stassen et al developed a model for the prediction of recurrence-free and melanoma-specific survival after sentinel lymph node biopsy (SLNB) in patients with melanoma.

A vaccine developer discusses a cancer vaccine that has been shown to potentially boost long-term overall postsurgical survival.

The risk for death, melanoma recurrence or metastasis was high among patients with this cancer and untreated obstructive sleep apnea vs. no sleep apnea.

A retrospective analysis of Medicare data revealed that between 2000 and 2017, immunohistochemistry (IHC) claims associated with melanoma diagnoses grew from 11% to 51%.

Monoclonal antibodies and immunotherapy are potent cancer treatments, but preventing treatment resistance to these therapies is challenging.

Unprotected exposure to ultraviolet (UV) radiation from the sun or other sources is a key risk factor for cutaneous melanoma, the most aggressive form of skin cancer. Having fair skin also increases the risk. The countries with the highest incidence of melanoma, including Australia, New Zealand, and Denmark, are largely composed of populations of European descent (1).

Neoadjuvant treatment with nivolumab and ipilimumab (nivo-ipi) is more effective but more toxic than anti-PD1 monotherapy for patients with high-risk, resectable melanoma, according to research published in JAMA Oncology.

A retrospective study analyzing tissue assays from patients with cutaneous melanoma demonstrated the promise of yes-associated protein (YAP) as a predictive biomarker for melanoma prognosis.

ROTTERDAM, Netherlands and SAN DIEGO, April 5, 2024 /PRNewswire/ — SkylineDx is pleased to announce two forthcoming scientific publications at the European Association for Dermato-Oncology congress, April 4-6, 2024.

A recent Scientific Reports study investigates whether genetically predicted childhood adiposity influences the risk of developing skin cancer in adulthood.

Michael R. Migden, MD, dermatologist, professor, Department of Dermatology, Division of Internal Medicine and Head and Neck Surgery, Division of Surgery, and program director, ACGME Fellowship:Micrographic Surgery and Dermatologic Oncology, The University of Texas MD Anderson Cancer Center, discusses efficacy data from the phase 1b/2 ARTACUS trial (NCT04349436) evaluating the oncolytic immunotherapy RP1 in patients with advanced non-melanoma cutaneous malignancies who underwent prior solid organ transplant.

In the setting of primary cutaneous melanoma, better adherence to annual dermatology follow-up visits was associated with reduced melanoma-specific mortality, according to study findings published in the Journal of the American Academy of Dermatology.

A prospective study evaluating the efficacy of an artificial intelligence (AI)–based clinical support system further demonstrated the reliability of AI or machine learning as a diagnostic tool in skin cancer.

According to 2 studies, this model has demonstrated the potential to assist in developing treatment and monitoring plans for early-stage melanomas.

An expert explained the importance of patient choice in treatment decisions for high-risk, resectable melanoma, based on their own treatment goals.

An investigational vaccine, SCIB1, has demonstrated activity when used in combination with nivolumab and ipilimumab in patients with advanced melanoma, according to research presented at the AACR Annual Meeting 2024.

Jeff Yorio, MD, discussed the unmet needs among patients with melanoma and plans for a phase 3 study assessing an mRNA vaccine.

Diagnostic accuracy of lesions was enhanced with combined dermoscopy and reflectance confocal microscopy, according to one study.

Melanoma is the deadliest form of skin cancer. With global incidence rates rising, new, more effective treatments are necessary to alleviate the health burden of the disease.

Researchers observed significant stepwise increases in median Breslow lesion thickness with increasing age at diagnosis of invasive melanoma in White patients in the United States and general population in Australia, according to a letter to the editor published in the Journal of Investigative Dermatology.

Melanoma is the deadliest form of skin cancer. With global incidence rates rising, new, more effective treatments are necessary to alleviate the health burden of the disease. Important advances in recent years include doctors using genetic tests to look for specific mutations they can target for more personalized, effective treatment.

A multicentric, single-arm diagnostic study created a decentralized federated learning model for the classification of invasive melanomas and nevi, showcasing comparable results to centralized data models.

Despite the high cure rate of localized cutaneous melanoma, many patients who undergo successful surgical resection experience severe anxiety and fear about the possibility of recurrence, according to findings published in JAMA Dermatology.

A mobile app that uses artificial intelligence, AI, to analyze images of suspected skin lesions can diagnose melanoma with very high precision.

Cells regulate RNA and protein abundance through a multi-layered process. Excitingly, peeling back one layer has revealed additional layers below, highlighting the complex nature of this process.

Lifileucel’s FDA approval marks a breakthrough in melanoma treatment, offering hope with promising antitumor activity. While its potential extends to various solid tumors, challenges persist.

Michelle Norton, skin cancer clinical nurse specialist at Velindre Cancer Centre, Cardiff, shares her perspectives on the burden of an advanced melanoma diagnosis, and how this digital Health Hub helps her to support her patients with advanced melanoma from diagnosis through to treatment.

On February 16, 2024, lifileucel (Amtagvi), a tumor-derived autologous T-cell immunotherapy, was granted accelerated approval for adults with unresectable or metastatic melanoma previously treated with a PD-1–blocking antibody, and if BRAF V600 mutation–positive, a BRAF inhibitor with or without a MEK inhibitor.

On October 13, 2023, nivolumab was approved for adjuvant treatment of completely resected stage IIB/C melanoma in patients aged 12 years and older.

Catherine J. Wu, of the Dana-Farber Cancer Institute in Boston, USA, is a pioneer in research that may result in the development of personalised vaccines to treat cancer.

Incidence of melanoma and keratinocyte (nonmelanoma) skin cancers, such as squamous cell and basal cell carcinomas (SCC and BCC, respectively), continues to increase, but mortality rates are stable or declining because of an explosion of treatment options, including numerous immunotherapy regimens, according to an oral presentation at the 2024 Oncology Nurse Advisor Summit.

A mobile app that uses artificial intelligence, AI, to analyse images of suspected skin lesions can diagnose melanoma with very high precision. This is demonstrated by a national study involving researchers from the University of Gothenburg. For the study, the app has been tested in clinical practice at primary care centers.

Vaccines developed using mRNA technology helped turn the tide during the COVID-19 pandemic. Now, researchers at NYU Langone Health’s Perlmutter Cancer Center and other cancer centers around the world are looking at using mRNA vaccines to personalize cancer treatment.

A population-based cohort study out of Norway has found that older men have a higher risk of developing second primary invasive melanoma following an initial primary melanoma, suggesting the benefits of increased surveillance in these patients.

According to a recent study published in Environmental Toxicology, regulatory T cells (Tregs) play a crucial role in immune suppression within the melanoma microenvironment.

Patients aged 40 years and younger saw longer interval times between melanoma incidences vs. patients aged 50 to 59 years and 80 years or older.

Craig L. Slingluff Jr., MD, and his team at UVA Cancer Center have developed a second-generation melanoma vaccine to treat the dangerous skin cancer.

An artificial intelligence (AI) mode was more accurate in assessing patient risks for skin cancer through the analysis of 2D facial images compared with more traditional risk-factor screening.

An ecological study revealed increasing rates of skin cancer overdiagnosis in white Americans.

An alternative dose of ipilimumab and nivolumab had less toxicity than a conventional dose, the results show.

Imaging after 1 week of treatment with pembrolizumab may help identify treatment responses in patients with metastatic melanoma.

A new study has shown that delays in diagnosis of melanoma in Europe due to COVID-19 lockdowns may have contributed to the loss of more than 100,000 life-years and costs that exceed £6 billion, mostly related to loss of productivity.

As the first cellular and tumor infiltrating lymphocyte (TIL) therapy product to be approved by the FDA for patients with solid tumors, lifileucel (Amtagvi) could usher in a paradigm shift in advanced melanoma management, thereby paving the way for several other TIL products to gain approval, according to Daniel Olson, MD.

During a Targeted Oncology™ Case-Based Roundtable™ event, Michael B. Atkins, MD, discussed what patient factors and other considerations affect the choice of immunotherapy for patients with advanced BRAF-negative melanoma. This is the first of 2 articles based on this event.

Each year, the Cancer Center Amsterdam (CCA) Foundation champions cutting-edge cancer research by funding promising proposals from CCA researchers. This ‘seed-funding’ empowers CCA scientists to pursue innovative research directions in support of our goal to cure cancer.

Patients with stage II or III cutaneous melanoma had significantly decreased life expectancy (LE) compared to people in the general population, according to study results published in the Journal of the American Academy of Dermatology.

Imagine finding out that your battle with melanoma, a formidable foe, might not be over with just one victory.

An oncology nurse and pharmacist discuss the multidisciplinary approach to administering TIL therapy in patients with advanced melanoma.

A transmembrane glycoprotein known as tyrosinase-related protein 1 (TYRP1) has been identified as a potential target for a CAR T-cell therapy that treats melanoma.

HCPs online celebrated the approval of lifileucel for advanced melanoma.

Age-related changes that cause the skin to stiffen and become less elastic may also contribute to higher rates of metastatic skin cancer in older people, according to research by investigators from the Johns Hopkins Kimmel Cancer Center.

Being a current smoker at the time of a clinical stage I and II primary cutaneous melanoma diagnosis was associated with an increased risk for melanoma-associated death compared with never smoking and former smoking, according to study results published in JAMA Network Open.

It is a promising time for cellular therapy, and combinations with gene modification or other systemic or local therapies bode well for solid tumor development of this TIL therapy platform.

In a study reported in The Lancet Oncology, De Angelis et al estimated the numbers of patients alive after a cancer diagnosis in Europe as of 2020.

During a Targeted Oncology™ Case-Based Roundtable™ event, Michael B. Atkins, MD, discussed dosing considerations and toxicity when choosing combination treatment for patients with melanoma. This is the second of 2 articles based on this event.

SAN DIEGO — According to data from the American Cancer Society (ACS), cutaneous melanoma was the fifth most common cancer in 2023, with an estimated 97,610 new cases and 7,990 deaths, following cancer of the colorectal area, lung and bronchus, prostate, and breast.

Patients with clinically localized primary cutaneous melanoma who smoked cigarettes at the time of diagnosis had an increased risk of melanoma-associated mortality, a cohort study showed.

A team of dermatology physician assistants recently reviewed the current and future potential of genomic testing in the realm of dermatology.

Through an analysis of tumor samples collected over time from patients with advanced melanoma, a Ludwig Cancer Research study has identified a set of preexisting conditions in tumors that predict whether such patients are likely to respond to a personalized immunotherapy known as adoptive T-cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL)

February 7, 2024—Scientists at Harvard T.H. Chan School of Public Health are peering deep inside lymph nodes to learn more about how cancer cells spread—and whether we may someday be able to halt metastasis through dietary modifications.

Patients with melanoma who smoke had an increased risk for melanoma-associated death.

A cannabis extract has shown positive results in slowing down melanoma cell growth and increasing cell death rates, a new in-vitro study finds.

Javid Moslehi, MD, presents Case 2, highlighting a 63-year-old female patient with metastatic melanoma on dual immunotherapy, illustrating treatment-related myocarditis and emphasizing key aspects of immunotherapy-induced cardiac toxicities.

Javid Moslehi, MD, shares expert perspectives on the diagnosis and management of immunotherapy-related myocarditis.

During a Targeted Oncology™ Case-Based Roundtable™ event, Evan J. Lipson, MD, and participants discussed tolerability factors that could influence the choice of frontline immunotherapy regimen for a patient with metastatic melanoma.

In a recent study published by Nature Communications, researchers uncovered a previously unknown method by which androgen-activated androgen receptors (ARs) increase fucosyltransferase 4 (FUT4) expression, which promotes melanoma invasiveness by interfering with adherens junctions (AJs).

Preferentially expressed antigen in melanoma has emerged as a target for treatment development in multiple solid tumors.

A recent study published in JAMA Network Open has unveiled a critical connection between smoking and the mortality rates associated with early-stage melanoma.

SECAUCUS, N.J., and SAN DIEGO, Feb. 13, 2024 /PRNewswire/ — Quest Diagnostics (NYSE: DGX), the nation’s leading provider of diagnostic information services, today announced the launch of MelaNodal Predict™, a highly advanced predictive gene expression test to help personalize treatment decisions for patients with melanoma, the deadliest form of skin cancer and one of the most common cancers in the United States.

A single-institution, retrospective cohort study evaluates knowledge gaps in clinical data on Black patients with melanoma.

In a study reported in the Journal of Clinical Oncology, Varey et al developed the Melanoma Institute Australia (MIA) calculator for predicting recurrence-free and overall survival in stage II melanoma and found that it outperformed modeling based on American Joint Committee on Cancer (AJCC)-8th edition melanoma staging.

Adjuvant nivolumab (Opdivo) continued to significantly improve relapse-free survival (RFS) over ipilimumab (Yervoy) in patients with resected stage III or IV melanoma, according to 7-year minimum follow-up efficacy data from the phase 3 CheckMate 238 study (NCT02388906) presented at the 2023 ESMO Congress.

A newly identified genetic marker could potentially predict which patients are likely to respond to immunotherapy in cancer types that have lacked such tools until now, according to a study published in Cancer Immunology Research, a journal of the American Association for Cancer Research.

In a recent study published in EClinicalMedicine, a group of researchers assessed the change in overall survival (OS) among advanced melanoma patients diagnosed between 2013 and 2021.

It is important to study the safety of targeted therapies in populations at increased risk of skin cancer, according to the researchers.

Paul D. Nathan, MBBS, PhD, FRCP, discusses the clinical significance of updated data on tebentafusp in metastatic uveal melanoma.

The test may help patients with melanoma safely avoid a sentinel lymph node biopsy.

Dr. Inderjit Mehmi and Dr. Omid Hamid from the Angeles Clinic, explain how therapies like targeted therapies, immunotherapy and T-cell therapies are improving outcomes for patients with advanced melanoma.

According to results from a retrospective cohort study, antibiotic exposure within 60 days prior to initiation of immune checkpoint blockade was associated with worse progression-free survival (PFS) and overall survival (OS) results among patients with treatment-naïve cutaneous or mucosal melanoma when compared with antibiotic exposure after initiation of immune checkpoint blockade.

Moderna and Merck have initiated V940-001, a phase 3 study evaluating vaccine mRNA-4157 and anti-PD-1 therapy Keytruda as postsurgical treatment for stage 2B to 4 melanoma.

A group of oncology experts provide forward-looking perspectives and clinical insights in the treatment of melanoma.

Scientists at the UCLA Health Jonsson Comprehensive Cancer Center have built and demonstrated the potential efficacy of a new chimeric antigen receptor (CAR) T-cell-based immunotherapy specifically designed to treat patients with cutaneous and rare subtypes of melanoma.

Researchers have revealed unprecedented insights into CD4+ T cells, a type of immune cell, which show promise for immunotherapies against melanoma, the most severe form of skin cancer

Almost 90% of white men and 85% of white women who received a diagnosis of melanoma in 2018 were likely overdiagnosed, according to a new study.

Oncologists reviewed data from clinical trials in the field of melanoma that could add clarity to treatment standards and lead to improved patient care.

Over 50% of all melanoma diagnoses among White patients in the United States may in fact be overdiagnoses, according to a recent study published by Adamson et al in BMJ Evidence-Based Medicine.

FDG PET/CT imaging detected metabolic changes in patients with advanced melanoma beginning immunotherapy in the first week.

CD4+ T-cells, primarily considered to play a supportive role in the anti-tumor immune response, have been seen to actively kill cancer cells in a mouse model of melanoma.

Adjuvant checkpoint inhibitor therapy is the standard of care for resectable melanoma. Although many patients derive lasting benefit from the treatment, a substantial number experience disease recurrence.

A panel of oncology experts explores the intricate balance between maintaining quality of life and managing toxicity in adjuvant immunotherapy for melanoma.

Patients with stage II or III cutaneous melanoma lost a total of 2,209 and 1,902 life-years, respectively.

Researchers have identified an epigenetic pathway involved in resistance to mitogen-activated protein kinase inhibitors, pointing the way to better patient treatment for resistant melanomas.

While the standard timing for imaging patients’ tumors after immunotherapy is three months, researchers found that imaging patients with melanoma after just one week of treatment illuminated metabolic changes in their tumors that corresponded with a response to the treatment and longer survival, according to new research from the Perelman School of Medicine

Researchers may have uncovered a novel epigenetic pathway involved in the development of treatment resistance in melanoma and a chemical reagent that may be effective in resensitizing treatment-resistant tumors to targeted therapies, according to a recent study published by Wu et al in The Journal of Clinical Investigation.

Afreen Shariff, MD, MBBS, examines the surveillance and management of immunotherapy-induced adrenal insufficiency in the context of melanoma, underscoring the importance of maintaining a heightened awareness for early detection.

Afreen Shariff, MD, MBBS, discusses managing immunotherapy-related diabetes in melanoma, emphasizing the critical need to detect sudden changes in blood sugar levels and advocating for a multidisciplinary approach.

A panel of expert oncologists explore novel therapies using monoclonal antibodies designed to target amyloid deposit, highlighting key data from the VITAL study.

Vd1-gd T cells, a rare type of immune cell, have been found to potentially predict how likely it is that certain patients with advanced skin cancer will be responsive to treatment via immunotherapy, according to recently published research.

The California-based DermTech has announced positive results from its Trust 2 study,tevaluating its system for ruling out melanoma showing a negative predictive value (NPV) of 99.7%.

Cutaneous melanoma is considered the deadliest form of skin cancer because it’s aggressive and tends to spread quickly through the body.

“When we talk about recurrence of melanoma, we actually worry more about what we cannot see, what’s on the inside,” Dr. Justine V. Cohen of the Dana-Farber Cancer Institute told CURE®.

In an analysis reported in JAMA Oncology, Kerekes et al found that initiation of immunotherapy at the end of life has increased over time in U.S. patients with metastatic cancers.

Patricia A. Possik, PhD, assistant investigator, Division of Cellular Biology, Brazilian National Cancer Institute, Rio de Janeiro, Brazil, discusses the importance of efforts to improve diversity, equity, and inclusion in melanoma research, including how a more diverse research landscape can influence the efficacy and relevance of treatment approaches in acral lentiginous melanoma.

The promising results were presented in a poster at the 2024 Winter Clinical Hawaii Dermatology Conference in Honolulu, Hawaii.

FRIENDSWOOD, Texas–(BUSINESS WIRE)–Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, will present new data across its dermatologic portfolio of commercially available and pipeline gene expression profile (GEP) tests at the 2024 Winter Clinical Dermatology Conference – Hawaii, being held Jan. 12-17 in Honolulu, Hawaii.

Patients with melanoma play a vital role in their own post-surgical care, as one expert explained to CURE®.

The initiation of immunotherapy at the end of life among patients with advanced cancers is increasing over time, according to findings from a cohort study led by investigators at the Yale School of Medicine.

The addition of a personalized mRNA vaccine to standard-of-care (SOC) pembrolizumab (Keytruda) improved survival outcomes vs pembrolizumab alone in resected high-risk melanoma, and monitoring ctDNA patterns over time can provide valuable insights into the degree of benefit patients can expect to achieve from the approach, according to Jeffrey S. Weber, MD, PhD.

A team of melanoma researchers with the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) is honored with the 2023 Paper of the Year distinction by the Journal of Clinical Oncology.

The DermaSensor device demonstrates a high rate of sensitivity in the detection of more than 200 types of skin cancers in a clinical study.

This is a video synopsis/summary of an OncLive Insights® involving Afreen Shariff, MD, MBBS; Javid Moslehi, MD; and Nikhil Khushalani, MD.

In the study led by the Peter Doherty Institute for Infection and Immunity (Doherty Institute) and published in Science Immunology, the researchers found that CD4+ T cells, traditionally called ‘helper T cells’ for their role in aiding the activation of other immune cells, are remarkably effective in controlling melanoma.

PHILADELPHIA—(Dec. 13, 2023)—Wistar researchers successfully tested a simple intervention that could unlock greater anti-tumor power in therapies that use T cells — an approach known as “cell-based therapy,” which uses specially designed T cells to fight cancer. Led by Dr. Hildegund C.J. Ertl — a professor in The Wistar Institute’s Vaccine & Immunotherapy Center — the team has proven an exciting concept: that the common cholesterol drug fenofibrate can boost T cells’ ability to destroy human tumors, as described in their new paper, “Treatment with the PPAR? agonist fenofibrate improves the efficacy of CD8+ T cell therapy for melanoma,” published in Molecular Therapy Oncolytics.

The Society for Immunotherapy of Cancer recently published insights into the management of patients with preexisting autoimmune disease, solid organ transplant recipients, elderly individuals, those living with HIV, pregnant patients, and those with rare noncutaneous subtypes of melanoma.

The Beach Boys’ iconic hit single “Good Vibrations" takes on a whole new layer of meaning thanks to a recent discovery by Rice University scientists and collaborators, who have uncovered a way to destroy cancer cells by using the ability of some molecules to vibrate strongly when stimulated by light.

Experts discuss treatment of patients with BRAF-mutated melanoma and symptomatic brain metastases, detailing radiation therapy, corticosteroid use, and the choice between BRAF/MEK inhibitor therapy and immunotherapy.

This is a video synopsis/summary of an OncLive Insights® discussion involving Afreen Shariff, MD, MBBS; Javid Moslehi, MD; and Nikhil Khushalani, MD.

Last year Emily Hayes received a phone call that made her think her life was over.

As 2023 comes to a close, Dermatology Times is taking a look back at the studies, therapies, and advances in vitiligo this year.

The Society for Immunotherapy of Cancer (SITC) has issued an expanded clinical practice guideline for the use of immunotherapy in patients with melanoma. The updated guideline was published in the Journal for ImmunoTherapy of Cancer.

A new study that corrects the underreporting of cancer among American Indian/Alaska Native populations shows the non-Hispanic American Indian and Alaska Native population, known as AI/AN, has the second highest incidence of melanoma.

The different variants of pediatric melanoma result in a wide array of presentations and disease outcomes, with the highest overall survival and recurrence rates associated with in-situ melanoma, according to study findings published in the Journal of American Academic Dermatology.

An overview of treatments for metastatic melanoma, including data updates regarding combination options.

Michael B Atkins, MD, shares insights on the prognosis of patient’s diagnosed with advanced melanoma and discusses the value of BRAF mutation testing.

Researchers from King’s College London, Guy’s and St Thomas’ Hospital Trust, and the Francis Crick Institute have discovered a rare type of T immune cell that can help predict whether a patient with advanced skin cancer may benefit from immunotherapy treatments.

Dr Atkins discusses current unmet needs in the treatment landscape for metastatic melanoma and provides an overview of some of the treatments currently under investigation that show promise.

The panel concludes their discussion with a call for continued research and collaboration, emphasizing the need for more understanding of targeted therapies, monitoring tools like ctDNA, and ongoing development in the field of BRAF mutant melanoma treatment.

Results from a long-term analysis of the phase 3 IMCgp100-202 trial indicate that tebentafusp results in better disease control and long-lasting responses in those with HLA-A*02:01–positive, previously untreated metastatic uveal melanoma.

PET/CT scans have the potential to predict brain metastasis in melanoma patients, according to a study published December 26 in Cancers.

More and more people living with cancer are being prescribed immunotherapy as an effective treatment option.

Nikhil Khushalani, MD, explores the significance of biomarker testing in melanoma, emphasizing the pivotal role of BRAF in understanding and managing this type of skin cancer.

Lifileucel demonstrated clinically meaningful antitumor activity alongside early, durable responses in patients with advanced melanoma following progression on checkpoint inhibitors.

Intravenous and intratumoral treatment with TILT-123 was found to be safe and feasible, with no dose-limiting toxicities when given alone or in combination with tumor infiltrating lymphocyte (TIL) therapy in patients with advanced, metastatic melanoma, according to data from a phase 1 trial (NCT04217473) presented at the 2023 ESMO Immuno-Oncology Annual Congress.

Michael B Atkins, MD, discusses first-line treatment options for a patient with stage IV BRAF-mutated melanoma. He also reviews data that may help guide treatment and sequencing decisions for patients with metastatic melanoma.

Michael B Atkins, MD, discusses first-line treatment options for a patient with stage IV BRAF-mutated melanoma. He also reviews data that may help guide treatment and sequencing decisions for patients with metastatic melanoma.

Beyond symptoms, doctors consider the psychosocial factors impacting treatment access and adherence, like insurance coverage, cost, family support, and preexisting conditions, when deciding between immunotherapy and targeted therapy for patients with BRAF-mutated metastatic melanoma.

Experts discuss a preference for ipilimumab/nivolumab as the frontline immunotherapy for patients with BRAF-mutant metastatic melanoma given its proven long-term efficacy but acknowledge nivolumab/relatlimab as an option with less toxicity, especially adrenal insufficiency.

Adolescents with a family history were more likely to be diagnosed with melanoma than controls (P < .046).

With artificial intelligence taking front and center in many aspects of our lives, will it be more prevalent in the dermatology practice than it is now?

New treatments can come with high price tags, and a population-based, retrospective study revealed that fewer than 25% of patients with cancer have a documented conversation about the financial aspects of their treatment.

Dr Rajiv Saxena and Dr Sushreesangita Behera from the Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi and Dr Witty Tyagi, from the Molecular Oncology Laboratory, National Institute of Immunology, New Delhi, have investigated whether nanodiamonds could stop tumour metastasis.

Patients with regressive melanoma had favorable relapse-free rates (HR = 0.52).

TAMPA, Fla. — Checkpoint inhibitors that activate the immune system to target cancer cells for destruction have revolutionized the treatment landscape for patients with advanced melanoma, leading to more options and improved patient survival.

Investigators used LIMS to classify melanoma samples as tumors and non-tumors.

Key opinion leaders explain that clinicians should warn patients with BRAF-mutated metastatic melanoma starting BRAF/MEK inhibitor therapy about short-term toxicities like fever, chills, and rash that can differ greatly from immunotherapy toxicities.

The study authors note that stress conditions result in an increased activity of the protein HDAC8, which promotes melanoma cell survival.

Checkpoint inhibitors that activate the immune system to target cancer cells for destruction have revolutionized the treatment landscape for patients with advanced melanoma, leading to more options and improved patient survival. Despite the approval of several immune checkpoint inhibitor regimens for melanoma, scientists do not completely understand their anticancer effects.

(Nanowerk News) A team of researchers based at the University of Toronto’s (U of T) Leslie Dan Faculty of Pharmacy has discovered a novel ionizable lipid nanoparticle that enables muscle-focused mRNA delivery while minimizing off-target delivery to other tissues.

Reducing how often patients receive immune checkpoint inhibitors can dramatically reduce medical costs while allowing patients to remain on lifesaving drugs, according to a recent study from Fred Hutchinson Cancer Center.

The study authors note that low skin cancer screening (SCS) participation, the participants’ better health than nonparticipants, and examination biases may be contributing factors to the insignificant results.

S. Weber, MD, PhD, deputy director, codirector, the Melanoma Research Program, NYU Langone Perlmutter Cancer Center, Laura and Isaac Perlmutter Professor of Oncology, NYU Grossman School of Medicine, discusses findings from the phase 2b mRNA-4157-P201/KEYNOTE-942 trial (NCT03897881) of mRNA-4157 (V940) in combination with pembrolizumab (Keytruda) in resected high-risk melanoma.

John Michael Kaczmar, MD, medical oncologist, associate professor, College of Medicine, Medical University of South Carolina (MUSC), MUSC Health, discusses future implications forthe use of fianlimab (formerly REGN 3767) in combination with cemiplimab-rwlc (Libtayo) for the treatment of patients with advanced melanoma.

In an analysis presented at the European Society for Medical Oncology (ESMO) Congress 2023 (Abstract LBA50) and reported in The New England Journal of Medicine by Jessica C. Hassel, MD, and colleagues, overall survival at 3 years in the phase III IMCgp100-202 trial continued to favor tebentafusp-tebn over investigator’s choice of treatment in previously untreated patients with HLA-A*02:01–positive unresectable or metastatic uveal melanoma.

Circulating tumour DNA (ctDNA) is emerging as a blood-based biomarker for many solid tumour types, including melanoma. Researchers at The University of Queensland (UQ) have now assessed ctDNA in the blood of patients with BRAF wild-type (BRAF WT) stage III and IV melanoma, finding that measuring ctDNA may lead to alternative treatment options and better outcomes.

The role of immunotherapy continues to evolve for the treatment of patients with skin cancer, now with physicians able to choose between the use of single-agent vs dual immunotherapy treatments.

ROTTERDAM, Netherlands and SAN DIEGO, Nov. 6, 2023 /PRNewswire/ — SkylineDx, an innovative molecular diagnostics company, is pleased to announce the forthcoming presentation of an impactful poster by Dr M.E. Egger at the upcoming Society for Melanoma Research Congress in Philadelphia. Dr. M.E.

Ze’ev Ronai, PhD, discusses key advancements in the treatment of patients with melanoma, including the discovery of NRAS and BRAF mutations, as well as the development of immunotherapy approaches.

During a Targeted Oncology™ Case-Based Roundtable™ event, Hussein A. Tawbi, MD, PhD, asked several participants to share their experiences treating patients with metastatic melanoma with nivolumab plus relatlimab. This is the second of 2 articles based on this event.

Pediatric and adolescent boys with primary invasive cutaneous melanoma present with more aggressive pathologic features that carry an increased risk for mortality compared with pediatric and adolescent girls, according to study results published in the Journal of the American Academy of Dermatology.’

Paul D. Nathan, MBBS, PhD, FRCP, consultant medical oncologist, Mount Vernon Cancer Centre, discusses the 3-year survival data from the phase 3 IMCgp100-202 trial (NCT03070392) of tebentafusp-tebn (Kimmtrak) in patients with previously untreated, HLA-A*02:01–positive metastatic uveal melanoma.

An expert reflects on the recent FDA approval of adjuvant Opdivo for patients with stage 2B or 2C melanoma.

When a patient with metastatic melanoma patient tests negative for the BRAF V600E mutation, doctors recommend sending the sample for next-generation sequencing testing which can take 2-3 weeks, during which time they may start immunotherapy if the patient has aggressive disease, but ideally should wait for results to guide treatment.

Expert panelists stress the importance of biomarker testing for BRAF mutations to guide treatment options when a patient is diagnosed with metastatic melanoma.

ROTTERDAM, Netherlands and SAN DIEGO, Oct. 31, 2023 /PRNewswire/ — SkylineDx an innovative diagnostics company focused on research & development of molecular diagnostics for oncology and inflammatory diseases, proudly announces the successful clinical validation and implementation of the clinicopathologic and gene expression profile (CP-GEP) model in a multicenter Dutch study focused on patients with melanoma.

A paper saw light in Current Issues in Molecular Biology.

The overall quality of care index (QCI) scores for patients with malignant melanoma improved globally from 1990 to 2019, although all-age disability-adjusted life years (DALYs) increased in the same period.

The suitability of NK cells for cancer therapy has been challenged by some investor and business interests because of limited efficacy data, but is this belief at the present stage of development of the immune therapy field?

Like most people, Gillian Mazy wasn’t excited about the prospect of having a chunk of skin on her face cut out and checked for cancer.

Pathologists specializing in dermatopathology tended to give higher-grade diagnoses vs. those without training (OR = 2.63).

Elizabeth Buchbinder, MD, assistant professor, Medicine, Harvard Medical School, senior physician, Medical Oncology, Dana-Farber Cancer Institute, discusses the investigation of treatment with nivolumab (Opdivo) maintenance therapy in patients with melanoma who experienced severe immune-related adverse effects (irAEs) associated with combination therapy with nivolumab and ipilimumab (Yervoy).

The panelists emphasize the importance of obtaining tissue for BRAF-mutation testing and dedicated tissue tracking in patients with metastatic melanoma, with immunohistochemistry followed by confirmatory next-generation sequencing, and discuss the promise of liquid biopsies like ctDNA as a future biomarker tracking modality.

Omid Hamid, MD, director, Melanoma Program, The Angeles Clinic and Research Institute, Cedars-Sinai, discusses the rationale for a phase 1 trial of fianlimab plus cemiplimab in patients with advanced melanoma who have received prior adjuvant PD-1 inhibitors.

Newswise — TAMPA, Fla. — Melanoma is the deadliest form of skin cancer because of its ability to quickly grow and spread throughout the body.

FRIDAY, Oct. 13, 2023 (HealthDay News) — The ability to detect skin cancer using artificial intelligence (AI) software has rapidly improved.

A new, bio-inspired drug restores the effectiveness of immune cells in fighting cancer, a team led by researchers at The University of Texas at Austin has found. In mouse models of melanoma, bladder cancer, leukemia and colon cancer, the drug slows the growth of tumors, extends lifespan and boosts the efficacy of immunotherapy.

In this Healio Video Perspective, Carol Shields, MD, discusses data investigating Fitzpatrick skin type and uveal melanoma presented at the Retina Society meeting.

During a Targeted Oncology™ Case-Based Roundtable™ event, Hussein A. Tawbi, MD, PhD, and participants discussed which first-line therapy they would recommend for a 78-year-old patient with metastatic melanoma and no BRAF-activating mutation. This is the first of 2 articles based on this event.

A new, bio-inspired drug restores the effectiveness of immune cells in fighting cancer, a team led by researchers at The University of Texas at Austin has found. In mouse models of melanoma, bladder cancer, leukemia and colon cancer, the drug slows the growth of tumors, extends lifespan and boosts the efficacy of immunotherapy.

Hussein Tawbi, MD, PhD, presents the case of a 78-year-old man with metastatic melanoma and shares his initial impressions.

Patients diagnosed with melanoma in 2020 presented with thicker, more ulcerated, and more advanced tumors despite reduced treatment delays, according to study results published in the Journal of the American Academy of Dermatology.

During a recent Institute for Value-Based Medicine® event, speakers discussed the use of immunotherapy and targeted therapy to treat melanoma and managing the toxicities of these treatments.

Pembrolizumab and mRNA-4157 demonstrated improvements in subgroups of resected melanoma, including those with BRAF-mutated tumors, in the phase 2 KEYNOTE-942 trial.

Results presented at 2023 ESMO showed a prolonged survival benefit in patients receiving adjuvant cemiplimab for stage II-IV cutaneous squamous cell carcinoma.

Antitumour responses were consistent with those previously reported for a broader population of patients with advanced melanoma

Danielle K. DePalo, MD, explains the lack of research directly comparing first-line treatment options for patients with unresectable melanoma in-transit metastases, expands on the safety and efficacy of 3 treatment modalities for these patients, and underscores the need for more data to inform the management of these patients.

Hussein Tawbi, MD, PhD, highlights the importance of BRAF mutations and LDH levels in diagnosing patients with metastatic melanoma and guiding treatment.

Among patients with invasive melanoma, improvements in overall survival (OS) rates due to the adoption of immunotherapy and targeted systemic therapies are further associated with greater economic and time burdens on the health care system, according to study results published in the Journal of the American Medical Association Dermatology.

Coverage from the Institute for Value-Based Medicine session with Minnesota Oncology.

The individualized neoantigen therapy mRNA-4157 (V940), combined with pembrolizumab (Keytruda), improved relapse-free survival (RFS) and distant metastasis-free survival (DMFS) compared with pembrolizumab alone in patients with high-risk resected melanoma, according to findings from the phase 2 KEYNOTE-942 trial (NCT03897881) presented at the 2023 European Society for Medical Oncology Congress (ESMO).

While access to invasive melanoma health care is fairly equitable across Queensland, people in regional areas are relying more on public hospitals for treatment rather than GPs or skin cancer specialists.

In a recent review published in the Life Journal, a group of authors reviewed image-processing techniques in machine learning (ML) for skin cancer detection using clinical images, evaluating their efficacy, available datasets, and challenges.

In comparing the period between 2007 and 2012 with 2018 and 2019, systemic therapy cost increased sixfold to ninefold.

During a Targeted Oncology™ Case-Based Roundtable™ event, April K.S. Salama, MD, and other physicians discussed which patients are more challenging when it comes to tolerating dual immunotherapy as frontline therapy for metastatic melanoma.

Inderjit Mehmi, MD, medical oncologist, Cedars-Sinai The Angeles Clinic and Research Institute, discusses the rationale for investigating the combination of fianlimab (REGN3767) and cemiplimab (Libtayo) in patients who have advanced melanoma with poor-risk features.

When Susanne Gabrielsson first learned about exosomes, her eyes widened. In 1999, she’d just started a postdoctoral fellowship at the Curie Institute in Paris.

Cutaneous immune-related adverse events (cirAEs) were associated with improved overall survival (HR = 0.61).

A recent eBioMedicine study found key risk factors associated with the development of melanoma in children and adolescents.

There is a high certainty of evidence that patients with CDKN2A mutation and a moderate or high nevus count had significantly increased risk for multiple primary melanomas, according to study results published in the British Journal of Dermatology.