Balancing Efficacy and Safety: Toxicity Considerations With Melanoma Immunotherapy

Source: Cancer Network, June 2025

Practice Setting Considerations and Treatment Selection

Key Discussion Points:

  • Immunotherapy management in community vs academic settings
  • Logistical factors influencing treatment selection
  • Community oncologist experience with immunotherapy regimens

Key Points for Physicians:

  • Community oncologists have developed increasing expertise in managing immune-related adverse events with combination regimens
  • Nivolumab/relatlimab adoption in community settings has been facilitated by its less intensive administration schedule (30-minute infusion every 4 weeks) and lower toxicity profile

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