Selective Role for Single-Agent Ipilimumab After Anti-PD-1 Failure in Melanoma

Source: Med Page Today, October 2024

Patients with wild-type metastatic melanoma that progressed on frontline PD-1 inhibition had almost a 2-year median overall survival (OS) when treated with single-agent ipilimumab (Yervoy), a small retrospective case review showed.

Median OS with post-progression ipilimumab was 23.2 months in patients with no targetable biologic markers versus 5.3 months and 4.5 months, respectively, for BRAF-mutated and NRAS-mutated tumors. Multivariate analysis showed that brain metastasis and BRAF or NRAS mutation were independent predictors of mortality.
“Despite the small sample size [N=44], our results indicate that a careful evaluation

Median OS with post-progression ipilimumab was 23.2 months in patients with no targetable biologic markers versus 5.3 months and 4.5 months, respectively, for BRAF-mutated and NRAS-mutated tumors. Multivariate analysis showed that brain metastasis and BRAF or NRAS mutation were independent predictors of mortality.
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