Archive | Clinical Trials

Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): Interim analysis of an open-label, single-arm, phase 1–2 trial

Researchers undertook this interim analysis of an ongoing phase 1–2 open-label trial, KEYNOTE-051, to not only establish the recommended phase 2 dose of pembrolizumab but also to verify its safety as well as antitumour activity in advanced paediatric cancer.

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Posted in Melanoma News, Health Professionals, Clinical Trials

No Significant Benefit Demonstrated with Nivolumab/Ipilimumab Versus Nivolumab Alone in Advanced Melanoma

The combination of nivolumab (Opdivo) with ipilimumab (Yervoy) showed no statistically significant benefit in patients with stage IIIB/C/D or stage IV (no evidence of disease) melanoma compared with nivolumab alone in the phase III CheckMate 915 study, missing the co-primary endpoint of recurrence-free survival (RFS) in patients with

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Posted in Melanoma News, Health Professionals, Clinical Trials

Whole-Brain Radiation Therapy vs Observation After Local Treatment of Melanoma Brain Metastases

In a phase III trial reported in the Journal of Clinical Oncology, Hong et al found that adjuvant whole-brain radiotherapy (WBRT) was not associated with a significant benefit in distant intracranial control vs observation after local treatment of patients with one to three melanoma brain metastases.

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Posted in Melanoma News, Health Professionals, Clinical Trials

TKI Combination vs Monotherapy for Advanced Melanoma and the Risk for CV Adverse Events

Risks of high-grade arterial hypertension and high-grade reduction in left ventricular ejection fraction (LVEF) are increased for patients with advanced melanoma treated with a combination of BRAF and MEK inhibitors compared with those treated with BRAF inhibitor alone, according to study results published in JAMA Open Network.

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Posted in Melanoma News, Health Professionals, Clinical Trials