Archive | Clinical Trials

A single dose of a PD-1 inhibitor before surgery predicts outcomes in melanoma patients

Source: Medical Express, March 2019 A single dose of a PD-1 inhibitor before surgery for melanoma can put patients in remission. Researchers from the Abramson Cancer Center at the University of Pennsylvania, who documented this finding in the largest cohort of patients to be treated with anti-PD-1 drugs before surgery, also showed that immune responses […]

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Posted in Melanoma News, Health Professionals, Clinical Trials

Neoadjuvant Anti-PD-1 Predicts Melanoma Outcomes

Source: Medpage Today, March 2019 A single dose of neoadjuvant anti-programmed cell death 1 (PD-1) therapy was effective in some stage IIIB/C and IV melanoma patients, leading to a disease-free survival (DFS) rate of 63% and an overall survival (OS) rate of 93% at 2 years, a small phase Ib clinical trial found. Alexander C. […]

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Posted in Melanoma News, Health Professionals, Clinical Trials

Paclitaxel with or without trametinib or pazopanib in advanced wild-type BRAF melanoma (PACMEL): A multicentre, open-label, randomised, controlled phase II trial

Source: MDLinx, March 2019 In a phase 2, randomized, open-label trial, researchers investigated the therapeutic effectiveness of inhibiting mitogen-activated protein kinase pathway by adding kinase inhibitors trametinib or pazopanib to paclitaxel chemotherapy in patients with advanced wild-type BRAF (BRAF-wt) melanoma. A total of 38 patients were randomized to paclitaxel alone, 36 were treated with paclitaxel and trametinib, […]

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Posted in Melanoma News, Health Professionals, Clinical Trials

A New Dosing Regimen for Nivolumab Plus Ipilimumab in Advanced Melanoma

Source: Cancer Network, March 2019 Among advanced melanoma patients in the CheckMate 511 phase IIIb/IV trial, raising the nivolumab dose to 3 mg/kg and lowering the ipilimumab dose to 1 mg/kg leads to a better safety profile without compromising efficacy. The trial results, recently published in the Journal of Clinical Oncology, may offer patients with advanced melanoma a […]

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Posted in Melanoma News, Health Professionals, Clinical Trials