Lymphoid Aggregates as Positive Prognostic in Overall Survival for Melanoma
Source: DocWireNews, November 2024
Because the prevalence and impact of immature precursor lymphoid structures known as lymphoid aggregates (LAs) remain unresolved in relation to metastatic cutaneous melanoma disease progression, researchers examined the characteristics and prognostic ability of LAs and tertiary lymphoid structures (TLSs) in histologic samples from patients with melanoma.
A research group led by Lilit Karapetyan, MD, assessed The Cancer Genomic Atlas-skin cutaneous melanoma digital slides and melanoma specimens from the University of Pittsburgh for the presence of LAs and TLSs with hematoxylin and eosin staining, multiple immunofluorescence (mIF), and transcriptomic analyses. Results were published in Journal of ImmunoTherapy of Cancer.
Cox proportional hazard regression models were used to assess the prognostic value associated with the presence of lymphoid structures in melanomas.