Building New Roads to a Melanoma Cure

Source: Cedars Sinai, April 2025

Just a handful of years ago, malignant melanoma was a diagnosis with few treatment options. Oncologists had no obvious roadmap for this perilous disease and were forced to explore beyond targeted therapies and chemotherapy.

Charged with building the roads to success, they turned to immunotherapy; the work has led to breakthrough treatments. Today, a stronger network of therapeutic pathways has emerged, with novel immunotherapies being key modalities in the oncologists’ armamentarium of treatments for melanoma and many other solid tumors.

Cedars-Sinai Cancer investigators are among the pioneers incorporating immunotherapy with other treatments for melanoma, aiming to not only tackle resistance and metastasis—two of the most challenging aspects of care—but to make treatments work better for all melanoma patients.

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