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Expression of IMP3 in a retrospective cohort of melanomas with selective lymph node biopsy

In malignant melanoma, the expression of insulin?like growth factor?II mRNA?binding protein 3 (IMP?3), a member of the insulin?like growth factor mRNA?binding protein family, has been demonstrated, but not in other benign skin lesions.

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Posted in Melanoma News, Publications, Scientific Publications

Comprehensive clinicopathological and molecular analysis of primary malignant melanoma of the oesophagus

In the present study, the researchers sought to illustrate the clinicopathological features, genetic alterations and therapeutic targets of primary malignant melanoma of the oesophagus (PMME).

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Posted in Melanoma News, Publications, Scientific Publications

Melanoma brain metastases have lower T-cell content and microvessel density compared to matched extracranial metastases

Although melanoma brain metastases (MBM) tend to respond to systemic therapy concordantly with extracranial metastases, little is known about differences in immune cell and vascular content between the brain and other metastatic sites.

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Posted in Melanoma News, Publications, Scientific Publications

The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression

The transcription factor NRF2 is the major mediator of oxidative stress responses and is closely connected to therapy resistance in tumors harboring activating mutations in the NRF2 pathway.

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Posted in Melanoma News, Publications, Scientific Publications