Study uncovers the role of NETO2-mediated regulation in melanoma progression
Source: Medical Xpress, August 2024
Cong Peng and others at the Department of Dermatology, Xiangya Hospital, Central South University, China, conducted a study titled “NETO2 promotes melanoma progression via activation of the Ca2+/CaMKII signaling pathway," which investigated the role of Neuropilin and tolloid-like 2 (NETO2) in melanoma, a deadly form of skin cancer.
The research, published in Frontiers of Medicine, explores how NETO2, a membrane protein, influences the progression of melanoma through the Ca2+/CaMKII signaling pathway.
The study begins by highlighting the importance of Ca2+ as a signaling ion in cellular functions such as proliferation, migration, and transcription factor activation. It notes that Ca2+ signaling is highly activated in melanoma, contributing to its growth and invasiveness.