Neoadjuvant Vidutolimod Plus Pembrolizumab Elicits Responses and Is Safe in Stage III Melanoma

Source: OncLive, June 2025

The neoadjuvant combination of pembrolizumab (Keytruda) with the TLR9 agonist vidutolimod (formerly CMP-001) generated higher pathologic complete response (pCR) rates vs pembrolizumab alone, as well as an acceptable safety profile, in patients with macroscopic, resectable stage III melanoma, according to Ahmad Tarhini, MD, PhD.

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