Scientists discover the ‘roadmap’ that aggressive cancer uses to spread around the body – identifying ways to block its escape

Source: The Institute of Cancer Research, February 2025

Image of human melanoma tissue, with melanoma cells in green and purple extracellular matrix fibres arranged perpendicular at the border of the tumour. Credit Oscar Maiques Carlos

Scientists have discovered a new way to predict which tumours will become aggressive before they metastasise and spread around the body.

New research, published in Nature Communications, reveals how cancer cells are altered by their surroundings, enabling them to change their shape and break out of a tumour. The discovery paves the way for treatments that will tackle cancer before it can spread.

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