Source: Genetic Engineering & Biotechnology News, June 2025
It often starts with something small—a dark spot on the skin that looks a little off. A dermatologist takes a closer look, runs a biopsy, and soon after, the diagnosis arrives: melanoma. If the cancer is advanced, treatment may include immune checkpoint inhibitors—drugs that help the body’s own immune system recognize and attack the cancer.
For some patients with aggressive melanoma—one of the deadliest forms of skin cancer—immune checkpoint inhibitors offer the potential for long-term remission. But while some people respond well to Immune Checkpoint Blockade (ICB) therapies, others are resistant to the treatment.