Although National Comprehensive Cancer Network (NCCN) and ASCO/Society of Surgical Oncology (SSO) guidelines and the Memorial Sloan Kettering Cancer Center (MSKCC) online nomogram are valuable for selecting patients with primary cutaneous melanoma for sentinel node (SN) biopsy, researchers aimed at generating an improved online risk calculator using alternative clinicopathologic parameters that may allow more accurate prediction of SN positivity.
Publications
Long noncoding RNA CCAT1 functions as a competing endogenous RNA to upregulate ITGA9 by sponging MiR-296-3p in melanoma
This inquiry was performed to determine the role of long noncoding RNA (lncRNA) colon cancer-associated transcript-1 (CCAT1) in melanoma.
Melanoma Journal Articles for May 2020
Please click on the link to see a list or melanoma journal citations that crossed the MRV desk this month.
Tumor immune profiling-based neoadjuvant immunotherapy for locally advanced melanoma
Given that the frequency of “exhausted” or checkpoint-positive (PD-1+CTLA-4+) cytotoxic lymphocytes (Tex) in the tumor microenvironment is correlated with response to anti-PD-1 therapy in metastatic melanoma, researchers ascertained if pretreatment Tex cells in locally advanced melanoma anticipated response to neoadjuvant anti-PD-1 blockade.