Long noncoding RNA CCAT1 functions as a competing endogenous RNA to upregulate ITGA9 by sponging MiR-296-3p in melanoma

Source: MDLinx, June 2020

This inquiry was performed to determine the role of long noncoding RNA (lncRNA) colon cancer-associated transcript-1 (CCAT1) in melanoma. By employing real-time quantitative polymerase chain reaction, melanoma tissues or cells were analyzed for the expression levels of CCAT1, miR-296-3p and Integrin alpha9 (ITGA9). The melanoma tissues and cells showed effectively increased CCAT1 vs matched controls, and deficiency of CCAT1 hindered cell glycolysis, proliferation, migration while induced apoptosis, which were abrogated by knockdown of miR-296-3p in melanoma cells. Additionally, the impacts of miR-296-3p overexpression on melanoma cells were shown to be abolished by ITGA9 overexpression.

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