Scientific Publications

This inquiry was performed to determine the role of long noncoding RNA (lncRNA) colon cancer-associated transcript-1 (CCAT1) in melanoma.

Please click on the link to see a list or melanoma journal citations that crossed the MRV desk this month.

Given that the frequency of “exhausted” or checkpoint-positive (PD-1+CTLA-4⁺) cytotoxic lymphocytes (Tex) in the tumor microenvironment is correlated with response to anti-PD-1 therapy in metastatic melanoma, researchers ascertained if pretreatment Tex cells in locally advanced melanoma anticipated response to neoadjuvant anti-PD-1 blockade.

Given that distinct somatic mutations that define clinical and histopathological heterogeneity in cutaneous melanoma may depend on host susceptibility to exogenous factors such as ultraviolet radiation, researchers conducted a retrospective study on 563 patients with melanoma by examining somatic mutations in BRAF, NRAS and TERT promoter.