Researchers intended to well-characterize patients at increased risk for melanoma following keratinocyte cancer, using a population-based cohort comprising 2,243 individuals with histologically-verified KC, selected from dermatology and pathology practices, and without a history of internal malignancy (1,363 BCC, 880 SCC).
Publications
Prognostic value of macrophage polarization markers in epithelial neoplasms and melanoma. A systematic review and meta-analysis
A systematic review and meta-analysis were performed to evaluate the correlation of proposed macrophage markers with prognosis across epithelial tumors and melanoma.
Tumor cell-derived angiopoietin-2 promotes metastasis in melanoma
Given that the role of the Angiopoietin (Angpt)-TIE signaling pathway is to control vascular maturation as well as to maintain the quiescent phenotype of resting vasculature, and scattered reports have shown tumor cells as a source of ANGPT2, researchers performed in situ hybridization-based detection of ANGPT2 and identified that a subset of melanoma patients exhibited a strong tumor cell expression of ANGPT2.
Scientists have identified protein involved in progression of lung cancer and melanoma
Scientists from Far Eastern Federal University (FEFU, Russia), University of Geneva (Switzerland), Minjiang University, and Fuzhou University (China) pointed out WDR74 protein playing an important role in lung cancer and melanoma primary tumors/metastases progression.