A simple blood test can detect early markers of “reinvigorated” T cells and track immune responses in metastatic melanoma patients after initial treatment with the anti-PD-1 drug pembrolizumab, researchers from the Abramson Cancer Center of the University of Pennsylvania report in new research being presented at the inaugural CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference. The new findings give more insight into how the anti-PD-1 therapy, approved last year by the U.S. Food and Drug Administration to treat metastatic melanoma, goes to work inside patients’ bodies, and potentially form the basis of a biomarker to predict which patients are most apt to respond to the immunotherapy.
MRV Research
Adjuvant GM-CSF, peptide vaccination fail to improve survival for advanced melanoma
Neither a peptide vaccination nor granulocyte-macrophage colony–stimulating factor improved RFS or OS in patients with locally advanced or stage IV melanoma following surgery, according to results from a phase 3 trial of the Eastern Cooperative Oncology Group.
Identifying protein that may predict response to PD-1 immunotherapy for melanoma
Mayo Clinic researchers have identified a protein marker whose frequency may predict patient response to PD-1 blockade immunotherapy for melanoma. An abstract of their findings was presented today at the American Association for Cancer Research International Cancer Immunotherapy Conference in New York City.
Team pinpoints immune changes in blood of melanoma patients on PD-1 drugs
A simple blood test can detect early markers of “reinvigorated" T cells and track immune responses in metastatic melanoma patients after initial treatment with the anti-PD-1 drug pembrolizumab, researchers from the Abramson Cancer Center of the University of Pennsylvania report in new research being presented at the inaugural CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference. The new findings give more insight into how the anti-PD-1 therapy, approved last year by the U.S. Food and Drug Administration to treat metastatic melanoma, goes to work inside patients’ bodies, and potentially form the basis of a biomarker to predict which patients are most apt to respond to the immunotherapy.