Measurements of circulating tumor DNA (ctDNA) before adjuvant targeted therapy and during follow-up identified patients with stage III melanoma at high risk for early disease recurrence, according to results of an analysis of patients from the COMBI-AD trial published recently in The Lancet Oncology.
2025
Childhood Sunburns Linked to Future Melanoma Risk
In a large cohort study, each additional blistering sunburn before the age of 15 years increased melanoma risk by approximately 3%, and the associated risk was not modified by personal sun sensitivity factors, such as eye and hair color.
How melanoma and other tumors succeed in hiding and resisting immunotherapy
Cutaneous melanoma, the most aggressive form of skin cancer, is characterized by its accumulation of a large number of mutations. Although some of these alterations should be recognized as a threat by our defenses, melanomas often escape immune system surveillance. As a result, more than half of patients do not generally respond to current immunotherapies. Understanding and avoiding this phenomenon is one of the greatest challenges in oncology today.
Undersleeping is a Potential Risk Factor for Cutaneous Melanoma
Two-sample Mendelian randomization analysis explored lifestyle factors such as sleep, smoking, alcohol consumption, and sedentary behavior.