Newswise — A fresh analysis performed at Tel Aviv University and the Sheba Medical Center unveils how melanoma tumor cells impact their nearby surroundings to aid their requirements – by generating fresh lymph channels in the dermis to penetrate further into the skin and extend throughout the body. The scientists hold the view that this novel finding might aid in the advancement of an immunization against this fatal cancer.
2023
Combination of mRNA-4157 With Pembrolizumab Improves Survival in Melanoma
In the phase 2 KEYNOTE-942 trial (NCT03897881), mRNA-4157 (V940) in combination with pembrolizumab (Keytruda) led to a reduced risk of developing distant metastasis or death by approximately 65% vs with pembrolizumab alone as adjuvant therapy in patients with resected melanoma at high risk of recurrence, according to findings presented at the 2023 ASCO Annual Meeting.
Adjuvant Chemotherapy Superior to Toripalimab in Resected Mucosal Melanoma
Chemotherapy is more effective than toripalimab as adjuvant therapy in patients with resected mucosal melanoma, according to research presented at the ASCO Annual Meeting 2023.
Updated Melanoma Guidelines: What Dermatologists Need to Know
In the past decade, advances in the understanding of melanoma have led to new therapeutic options and treatment strategies. In response, late last year the American Academy of Dermatology (AAD) released updated guidelines on the management of primary cutaneous melanoma.