According to the Cancer Council of Australia, skin cancer is the most common type in the country, with around 434,000 new cases diagnosed each year. Around 99% of those are caused by exposure to ultraviolet (UV) radiation from the sun.
2022
Atezolizumab Triplet Induces Intracranial Responses in BRAF V600-Mutated Metastatic Melanoma
In patients with BRAF V600-mutated melanoma and central nervous system metastases, treatment with atezolizumab to vemurafenib plus cobimetinib achieved a good intracranial overall response rate. Responses were all achieved with the combination in patients with BRAF wild-type tumors.
Calls for more precise tools to detect melanoma
Research has shown a dramatic increase in the treatment of these abnormalities in Australia.
Penn Research Shows that DOPA Protects Against Melanoma, Identifies Potential New Therapeutic Targets to Treat Melanoma
PHILADELPHIA – People with light skin tones are far more likely to develop melanoma skin cancer than people with dark skin tones. This large disparity results from far more than can be explained by the UV protective effects of melanin pigment, and results in large part from the melanin precursor DOPA, and its ability to inhibit CHRM1, according to new research from the Perelman School of Medicine at the University of Pennsylvania. Additionally, the researchers found that inhibiting FOXM1, a transcription factor downstream of CHRM1, also inhibits melanoma.