IBI363 has earned fast track designation from the FDA for the treatment of previously treated unresectable advanced melanoma.
Health Professionals
Melanoma Deadlier in Men Due to Age-Related Changes in Their Fibroblasts
The results of newly reported research in human cells and in mice, carried out by scientists at Johns Hopkins Kimmel Cancer Center, suggest that age-related changes in fibroblasts contribute to the development of aggressive, treatment-resistant melanoma in males. The researchers, co-led by Ashani Weeraratna, PhD, the Bloomberg Distinguished Professor, E.V. McCollum Professor, and chair of the department of biochemistry and molecular biology at Johns Hopkins, found that human skin fibroblasts—cells that create the skin’s structure—show age-and sex-specific changes in proliferation and stress response, and that male fibroblasts age faster due to elevated levels of reactive oxygen species (ROS).
Melanoma In Situ of Smaller Size Has Low Recurrence With 5-mm Margin for Excision
Excision with 5-mm margins for melanoma in situ that is less than 10 mm in size on low-risk body sites is associated with a low recurrence rate, according to a study published in JAMA Dermatology.
UV Exposure Continues to Be Linked to Increased Melanoma Incidence in Those With Fair Skin
WEDNESDAY, Sept. 11, 2024 (HealthDay News) — Ultraviolet (UV) exposure remains associated with an increased risk for melanoma in patients with Fitzpatrick skin types I to IV, according to a systematic review and meta-analysis published online Sept. 4 in the Journal of the European Academy of Dermatology and Venereology.