Shortfalls in clinical management may explain why tumor upstaging in invasive melanoma is associated with worse survival outcomes, according to study findings published in the Journal of the American Academy of Dermatology.
Of Interest
mmune Checkpoint Inhibitors for Advanced Melanoma: 10-Year Outcomes Turn Heads
The final, 10-year results of the international randomised clinical trial known as CheckMate 067 report that the median overall survival with advanced melanoma is nearly 72 months with the combination of nivolumab + ipilimumab, nearly 37 months with nivolumab monotherapy, and only 20 months with ipilimumab monotherapy. Both agents are immune checkpoint inhibitors, but their immune targets differ.
Melanoma survival linked to tumor thickness
Researchers at The University of Sydney have identified a significant increase in melanoma-related death risk for patients with thin primary tumors measuring between 0.8 and 1.0 millimeters compared to those with thinner lesions.
A European project led by IDIBAPS-Hospital Clínic Barcelona studies the efficacy of immunotherapy for childhood melanoma for the first time
Conducted as part of the MELCAYA project, the study demonstrates that anti PD-1 antibody immunotherapy is safe for children and adolescents. Furthermore, whilst it is effective for patients who have previously had their tumour removed, its effectiveness is diminished in more advanced cases, where metastasis has already spread to other organs.