Of Interest

During a live event, Ahmad Tarhini, MD, PhD, discussed key melanoma trials with varying survival and toxicity profiles.
This article is part 1 of a 2-part series from a Case-Based Roundtable event.

Scientists at the Icahn School of Medicine at Mount Sinai have discovered a possible reason why some cases of melanoma—a dangerous form of skin cancer—spread to the brain. Their study, published in Molecular Cell, highlights the role of a group of proteins called the PBAF chromatin remodeling complex in keeping melanoma from getting worse.

Researchers identified key ancestral contributions among patients with high-risk melanoma in a US intergroup phase 3 trial. Most cases genetically clustered with European reference populations, with smaller subsets aligning with admixed American and East Asian ancestries.

Overall survival (OS) in women with genital tract melanoma (GTM) is improved with immunotherapy, according to study findings published in Melanoma Research.