Archive | Clinical Trials

Adjuvant Whole-Brain RT Does Not Improve Outcomes in Melanoma Brain Mets

Results from a phase III international trial have shown that adjuvant whole-brain radiotherapy (WBRT) does not improve outcomes in patients with melanoma brain metastases

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Posted in Melanoma News, Health Professionals, Clinical Trials

Dabrafenib-trametinib combination confers durable survival benefit in BRAF-mutated metastatic melanoma

About one-third of patients with unresectable or metastatic melanoma with a BRAF V600E or BRAF V600K mutation who received first-line dabrafenib plus trametinib in two clinical trials achieved 5-year OS, according to results of a data analysis published in The New England Journal of Medicine.

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Posted in Melanoma News, Health Professionals, Clinical Trials

Personalized Cancer Vaccine NEO-PV-01 Shows Promise in 3 Types of Advanced Cancer

New results released by Neon Therapeutics1 have shown promising, early results for their NEO-PV-01 personalized neoantigen vaccine in combination with nivolumab across 3 different types of advanced cancer.

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Posted in Melanoma News, Health Professionals, Clinical Trials

Atezolizumab/Cobimetinib Combo Misses PFS Endpoint in BRAF V600 Wild-Type Melanoma

Source: OncLive, July 2019 The combination of atezolizumab (Tecentriq) and cobimetinib (Cotellic) did not improve progression-free survival (PFS) compared with pembrolizumab (Keytruda) in patients with previously untreated BRAF V600 wild-type melanoma, missing the primary endpoint of the phase III IMspire170 trial (NCT03273153).1 The safety profile observed with the combination regimen was consistent with the known safety profiles […]

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Posted in Melanoma News, Health Professionals, Clinical Trials