Archive | Clinical Trials

Personalized Cancer Vaccine NEO-PV-01 Shows Promise in 3 Types of Advanced Cancer

New results released by Neon Therapeutics1 have shown promising, early results for their NEO-PV-01 personalized neoantigen vaccine in combination with nivolumab across 3 different types of advanced cancer.

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Posted in Melanoma News, Health Professionals, Clinical Trials

Atezolizumab/Cobimetinib Combo Misses PFS Endpoint in BRAF V600 Wild-Type Melanoma

Source: OncLive, July 2019 The combination of atezolizumab (Tecentriq) and cobimetinib (Cotellic) did not improve progression-free survival (PFS) compared with pembrolizumab (Keytruda) in patients with previously untreated BRAF V600 wild-type melanoma, missing the primary endpoint of the phase III IMspire170 trial (NCT03273153).1 The safety profile observed with the combination regimen was consistent with the known safety profiles […]

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Posted in Melanoma News, Health Professionals, Clinical Trials

PFS Not Improved With Atezolizumab/Cobimetinib Combo in Phase III IMspire170 Trial

Source: Targeted Oncology, July 2019 The phase III IMspire170 trial (NCT03273153) failed to meet its primary endpoint according to topline results from the study. The combination of atezolizumab (Tecentriq) and cobimetinib (Cotellic) did not improve progression-free survival compared with pembrolizumab (Keytruda) in patients with previously untreated BRAF V600 wild-type melanoma. The safety profile observed with the combination […]

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Posted in Melanoma News, Health Professionals, Clinical Trials

Dabrafenib/Trametinib Combo Shows Long-Term Survival Benefit in Metastatic Melanoma

Source: Specialty Pharmacy Times, July 2019 First-line treatment with dabrafenib (Tafinlar) and trametinib (Mekinist) provided overall survival (OS) and long-term progression-free survival (PFS) benefits in patients with unresectable or metastatic BRAF-mutation positive melanoma, according to a pooled analysis of 2 phase 3 trials. Metastatic melanoma often results in poor prognosis for patients who are diagnosed. Each […]

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Posted in Melanoma News, Health Professionals, Clinical Trials