Researchers investigated the efficacy of the tumor microenvironment-derived protein S100A8/A9 as a prognostic marker for melanoma patients, also in the setting of immunotherapy. Using a cDNA library and three independent tissue-microarrays (TMA), they analyzed S100A8/A9 gene and protein expression on melanocytic nevi, primary melanomas and metastases.
Scientific Publications
Melanoma Journal Articles for November 2019
Please click on the link to see a list of melanoma journal citations that crossed the MRV desk this month.
Association of indoor tanning exposure with age at melanoma diagnosis and BRAF V600E mutations
Given the limited knowledge on how indoor tanning promotes melanoma development, researchers assessed indoor tanning use in patients with melanomas in sun-exposed skin, and analyzed the link between indoor tanning exposure and clinicopathological and molecular features.
TLR9 Agent Triggers Durable Response in Metastatic Melanoma
The use of CMP-001, an intratumoral toll-like receptor 9 (TLR9) agonist, is capable of triggering durable responses when used in combination with pembrolizumab (Keytruda) for patients with PD-1 resistant metastatic melanoma according to results from a phase Ib study presented at the Society for Immunotherapy of Cancer’s 34th Annual Meeting (SITC 2019).1