Since the precise role of aryl hydrocarbon receptor (AHR) in melanoma is mostly unclear, researchers reported a functional effect of AHR activation on inflammation?induced melanoma cell dedifferentiation and the development of lung metastases in a mouse model.
Scientific Publications
Association of BRAF V600E/K mutation status and prior BRAF/MEK inhibition with pembrolizumab outcomes in advanced melanoma: Pooled analysis of 3 clinical trials
Researchers conducted this post hoc analysis of 3 randomized clinical trials (KEYNOTE-001, KEYNOTE-002, and KEYNOTE-006) to explore the correlation of BRAF wild-type (WT) or BRAF V600E/K-mutant status and BRAF inhibitor (BRAFi) with or without MEK inhibitor (MEKi) therapy with the response to pembrolizumab.
Final analysis of a phase II study of nivolumab in combination with ipilimumab for unresectable chemotherapy-naive advanced melanoma
Researchers conducted this final analysis of a multicenter, open?label, uncontrolled phase II study to test the long?term safety and effectiveness in treatment?naive Japanese patients with advanced melanoma, including acral or mucosal subtypes, and subsequent therapy after discontinuation of the investigational agents.
Melanoma Journal Articles for July 2020
Please click on the link to see a list of melanoma journal articles that came across the MRV desk recently