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Late recurrence of melanoma after ten years – Is the course of the disease different from early recurrences?

In this retrospective study involving 1,537 melanoma patients, researchers examined clinicopathological characteristics and the course of melanoma to identify prognostic factors, contrasting early and late recurrence (LR), defined as melanoma recurrence 10 years after the first diagnosis, in patients followed at the Department of Dermatology of the University Hospital of Tübingen between February 1976 and June 2015.

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Tumor microenvironment-derived S100A8/A9 is a novel prognostic biomarker for advanced melanoma patients and during immunotherapy with anti-PD-1 antibodies

Researchers investigated the efficacy of the tumor microenvironment-derived protein S100A8/A9 as a prognostic marker for melanoma patients, also in the setting of immunotherapy. Using a cDNA library and three independent tissue-microarrays (TMA), they analyzed S100A8/A9 gene and protein expression on melanocytic nevi, primary melanomas and metastases.

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