Given that the frequency of “exhausted” or checkpoint-positive (PD-1+CTLA-4+) cytotoxic lymphocytes (Tex) in the tumor microenvironment is correlated with response to anti-PD-1 therapy in metastatic melanoma, researchers ascertained if pretreatment Tex cells in locally advanced melanoma anticipated response to neoadjuvant anti-PD-1 blockade.
Publications
Clinical, environmental, and histological distribution of BRAF, NRAS and TERT promoter mutations among cutaneous melanoma patients. A retrospective study of 563 patients
Given that distinct somatic mutations that define clinical and histopathological heterogeneity in cutaneous melanoma may depend on host susceptibility to exogenous factors such as ultraviolet radiation, researchers conducted a retrospective study on 563 patients with melanoma by examining somatic mutations in BRAF, NRAS and TERT promoter.
Incidence and survival of patients with conjunctival melanoma in Europe
The incidence and survival of patients with conjunctival melanoma in Europe were determined via performing a cohort study of 724 patients (512 [70.7%]: 55 years or older; 366 [50.6%] were female) with conjunctival melanoma from population-based data of 41 cancer registries.
Factors Affecting Sentinel Node Metastasis in Thin (T1) Cutaneous Melanomas: Development and External Validation of a Predictive Nomogram
In view of the observation that for thin melanomas (T1; ? 1 mm), regional node metastasis determined by sentinel node biopsy (SNB) is an important prognostic factor, researchers here investigated the determinants of sentinel node (SN) status for incorporation into an externally validated nomogram to better define patients with T1 disease for SNB.