Researchers conducted this post hoc analysis of 3 randomized clinical trials (KEYNOTE-001, KEYNOTE-002, and KEYNOTE-006) to explore the correlation of BRAF wild-type (WT) or BRAF V600E/K-mutant status and BRAF inhibitor (BRAFi) with or without MEK inhibitor (MEKi) therapy with the response to pembrolizumab.
Publications
Final analysis of a phase II study of nivolumab in combination with ipilimumab for unresectable chemotherapy-naive advanced melanoma
Researchers conducted this final analysis of a multicenter, open?label, uncontrolled phase II study to test the long?term safety and effectiveness in treatment?naive Japanese patients with advanced melanoma, including acral or mucosal subtypes, and subsequent therapy after discontinuation of the investigational agents.
Melanoma Journal Articles for July 2020
Please click on the link to see a list of melanoma journal articles that came across the MRV desk recently
Urethral involvement is associated with higher mortality and local recurrence in vulvar melanoma: A single institutional experience
Given a notoriously poor local control in vulvar malignant melanoma (VMM) with recurrence rates of 30-50% vs nearly 3% in cutaneous melanomas, researchers analyzed clinicopathologic characteristics of women suffering from VMM (n=37), following reviewing three decades of clinical follow up data in their institutional databases.