Groundbreaking work in mapping damaged DNA repair in the human genome reached a milestone at the University of North Carolina School of Medicine and Lineberger Comprehensive Cancer Center. The new study may have implications in helping treat patients with melanoma whose cells have become cancerous due to UV radiation damage and have overcome common chemotherapy agents through DNA repair.
MRV Research
Melanoma may metastasize in less radioactive sentinel lymph nodes
Microscopic melanoma metastases may occur in lymph nodes other than the hottest node, thus warranting their removal, according to results of a single-institution study.
Advanced melanoma risk greater in organ transplant recipients compared with general population
Organ transplant recipients had a greater risk of advanced melanomas at diagnosis and melanoma-specific death compared with the general population, according to recently published study results.
Overcoming Beta-Catenin Signaling May Improve Immunotherapy for Melanoma
Researchers from the University of Chicago in Illinois have found that metastatic melanoma tumors shield themselves from T cells by producing high levels of beta-catenin, and that beta-catenin prevents T cell invasion and ultimately undermines immunotherapy, a new study published in the journal Nature has shown.