MRV Research

Beyond BRAF: Emerging Agents Aim at Other Melanoma Targets

Targeted therapy for melanoma is much more than just BRAF inhibition.

While more than half of cutaneous melanoma tumors are BRAF-positive, agents that target the other 3 subtypes—RAS mutant, NF1 mutant, and triple wild-type—identified by the Cancer Genome Atlas (TCGA) in 2015 now have the increasing potential to improve survival for non-BRAF patients, says Jason Luke, MD, an assistant professor of Medicine at the University of Chicago Medicine.

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