Neil Box and colleagues show how genetics and childhood behaviors contribute to adult melanoma risk.
MRV Research
UC IRVINE, ITALIAN RESEARCHERS CREATE FIRST INHIBITOR FOR ENZYME LINKED TO MELANOMA, LUNG AND PROSTATE CANCERS
Recent studies showing acid ceramidase (AC) to be upregulated in melanoma, lung and prostate cancers have made the enzyme a desired target for novel synthetic inhibitor compounds. This week in Angewandte Chemie, a top journal in chemistry, scientists with UC Irvine School of Medicine and the Italian Institute of Technology describe the very first class of AC inhibitors that may aid in the efficacy of chemotherapies.
Genetic Diversity May Improve Treatment Response in Melanoma
Evidence suggests a genetic basis for clinical response to cytotoxic T-lymphocyte antigen 4 (CTLA-4) blockade in melanoma, according to research published online Nov. 19 in the New England Journal of Medicine.
TNF Inhibitors Not Tied to Higher Melanoma Risk in RA
Rheumatoid arthritis patients who are treated with tumor necrosis factor inhibitors (TNFi) do not have an increased risk of melanoma, according to a large collaborative study organized by the European League Against Rheumatism (EULAR).