Amgen has high hopes for its new cancer vaccine, barreling toward global approvals with positive data in melanoma. But a narrow miss on one key endpoint could present a major hurdle, and Amgen will soon get a chance to defend the treatment before a panel of FDA advisers.
MRV Research
Late Melanoma Patients Will Need Several Lines of Therapy, Intralesional Treatment Promising Says New Paper
Despite advances in melanoma treatment, many patients with unresectable, multiple or advanced locally/regionally metastatic stage IIIB/C or stage IV M1a melanoma will need several lines of therapy according to a recent paper in Current Opinion in Oncology.
Researchers Pinpoint Chronic Inflammation In the Development of Skin Cancer
Inflammation is a process by which the immune system responds to a disease or injury. Chronic inflammation, however, has been linked to several types of cancers, such as basal cell carcinoma, lung, liver, colon cancer and others. Although this association is acknowledged, research has not been able to explain the cellular mechanisms that are involved in this process.
Lack of RNA ‘editing’ leads to melanoma growth and metastasis
The importance of RNA editing in melanoma has been demonstrated by scientists at The University of Texas MD Anderson Cancer Center. The study revealed that a lack of RNA editing, a process by which information inside RNA molecules is transformed, leads to tumor growth and progression through manipulation of proteins.