2025

Moffitt Study Finds New Immunotherapy Strategy for Enhancing Melanoma Treatment

Recent advancements in the melanoma treatment paradigm have drastically improved outcomes and changed the diagnosis of metastatic melanoma from a horrible prognosis to a potentially curable one. DocWire News spoke to John Fruehauf, MD, field medical director at Evolent, about how new therapies have improved the landscape of metastatic melanoma care.

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New immunotherapy strategy targets macrophage receptors to enhance melanoma treatment

Researchers from Moffitt Cancer Center have found a new way to boost cancer immunotherapy by targeting a protein called macrophage receptor with collagenous structure, or MARCO. Their study, published in the Journal for ImmunoTherapy of Cancer, shows that blocking MARCO in combination with a type of immunotherapy known as anti-CTLA4 therapy, significantly enhances tumor regression in melanoma, the deadliest form of skin cancer.

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