Recent advancements in the melanoma treatment paradigm have drastically improved outcomes and changed the diagnosis of metastatic melanoma from a horrible prognosis to a potentially curable one. DocWire News spoke to John Fruehauf, MD, field medical director at Evolent, about how new therapies have improved the landscape of metastatic melanoma care.
2025
Subcutaneous Nivolumab Reduces Burden of Melanoma Care, Expert Says
In December, the U.S. Food and Drug Administration (FDA) approved nivolumab and hyaluronidase-nvhv (Opdivo Qvantig) for subcutaneous injection across all of nivolumab’s approved adult solid tumor indications, including melanoma.
Report Highlights Role of Cancer-Associated Fibroblasts in Melanoma Metastases
The study could open the door to potential novel therapeutic targets.
New immunotherapy strategy targets macrophage receptors to enhance melanoma treatment
Researchers from Moffitt Cancer Center have found a new way to boost cancer immunotherapy by targeting a protein called macrophage receptor with collagenous structure, or MARCO. Their study, published in the Journal for ImmunoTherapy of Cancer, shows that blocking MARCO in combination with a type of immunotherapy known as anti-CTLA4 therapy, significantly enhances tumor regression in melanoma, the deadliest form of skin cancer.