Scientists at the Icahn School of Medicine at Mount Sinai have discovered a possible reason why some cases of melanoma—a dangerous form of skin cancer—spread to the brain. Their study, published in the latest issue of Molecular Cell, highlights the role of a group of proteins called the PBAF chromatin remodeling complex in keeping melanoma from getting worse.
2025
Genetic Ancestry and Immunotherapy Response in High-Risk Melanoma
Ahmad Tarhini, MD, PhD, professor and senior member in cutaneous oncology and immunology at Moffitt Cancer Center, discusses inherited genetic variations and genetic ancestry, particularly for patients with high-risk melanoma. With a longstanding focus on improving immunotherapy outcomes and mitigating treatment-related toxicities, Tarhini and his team aim to bridge critical knowledge gaps in precision oncology through this work.
Gene-based blood test may predict melanoma recurrence
Researchers evaluated a blood test’s ability to predict recurrence in patients with stage 3 melanoma.
Dr Moschos on Treatment Strategies With Adoptive T-Cell Therapy in Melanoma
Stergios J. Moschos, MD, an associate professor of medicine in the Department of Medicine in the Division of Oncology at the University of North Carolina (UNC) Chapel Hill School of Medicine, UNC Health, emphasized the importance of appropriately administering bridging therapy to patients who are slated to receive the adoptive T-cell therapy lifileucel (Amtagvi).