Excessive UV radiation damages DNA in skin cells producing genetic mutations that can lead to skin cancer.
2024
Melanoma: predicting immunotherapy-induced side effects
Scientists at NYU Langone Health and its Perlmutter Cancer Center have revealed that an activity pattern in genes that build spleen tyrosine kinases can predict which melanoma patients are likely to have severe side effects from immunotherapy.
Pattern in Protein Production May Be Predictive of Side Effects From Immunotherapy in Patients With Melanoma
An activity pattern in certain genes responsible for building proteins known as spleen tyrosine kinases may predict the occurrence of severe side effects from immunotherapy in patients with melanoma, according to a recent study published by Monson et al in Clinical Cancer Research.
Gene signature predicts severe adverse events from ICI therapy for melanoma
The spleen tyrosine kinase pathway was upregulated in patients that had severe toxicities from immune checkpoint inhibitor therapy.