TVEC for Advanced Melanoma Yields Stunning Results in 3-Center Study

Source: Cancer Therapy Advisor, April 2019

A 3-center studyusing viral therapy talimogene laherparepvec (TVEC; Imlygic) in advanced melanoma has reported some of the best patient response rates since the drug was approved by the US Food and Drug Administration (FDA) in 2015.1

The research involved patients from Emory University, Atlanta, Georgia; the Moffitt Cancer Center, Tampa, Florida; and The University of North Carolina (UNC), Chapel Hill; monitored between 2015 and 2018. It found that 39% of patients achieved a complete local response and 18% achieved a partial response to therapy, with follow-up times ranging from 3 months to 28 months.

This represents a significant improvement compared with the original OPTiM trial,2 which led to the FDA approval of TVECand shows that the use of the therapy translates well to “real-world” use in cancer centers outside of the well-defined parameters of a clinical trial. However, just under half of patients don’t respond to TVEC at all, and the next big step to increasing its efficacy is to find out why.

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