The predictive and prognostic significance of cell-free DNA concentration in melanoma

Source: MDLinx, June 2020

In this study with a discovery cohort (n = 20) and expansion cohort (n = 166) including metastatic melanoma patients and healthy donors (n = 116), researchers sought to validate universal predictive and prognostic biomarkers, given that most of the liquid-biopsy biomarkers depend on the analyses of oncogenic mutations, however, approximately 20% of melanoma patients are wild-type. They investigated the diagnostic, predictive as well as prognostic potential of cell-free DNA (cfDNA) concentration, as well as established a cfDNA threshold for risk stratification. High cfDNA was related to presence of metastases and higher AJCC stage, as revealed by the measurement of baseline cfDNA level.

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