Talimogene Laherparepvec Plus Ipilimumab Promising for Advanced Melanoma
Source: Cancer Therapy Advisor, June 2017
Talimogene laherparepvec plus ipilimumab improves the overall response rate (ORR) over ipilimumab alone among patients with unresected, advanced melanoma, according to a study presented at the 2017 American Society of Clinical Oncology (ASCO) meeting in Chicago, Illinois.1
Talimogene laherparepvec, an engineered oncolytic virus, is designed to replicate within tumors and to stimulate anti-tumor activity through granulocyte-macrophage colony-stimulating factor (GM-CSF) production.
For this phase 2, randomized trial (ClinicalTrials.gov Identifier: NCT01740297), researchers evaluated whether combining talimogene laherparepvec with ipilimumab, a CTLA-4 inhibitor, would improve outcomes among patients with melanoma over ipilimumab alone.