Study Shows why Late-stage Metastatic Melanoma Resists Treatment
Source: Onco’Zine, March 2023
An in-depth analysis of 14 patients who died from incurable melanoma has revealed that changes to the order, structure and number of copies of tumor DNA could cause some skin cancers to resist treatment. These changes also explain how melanoma can spread to other parts of the body.
The research, published in the March edition of the journal Cancer Discovery, was led by scientists and clinicians at the Francis Crick Institute, UCL and The Royal Marsden, in London, UK. The study is part of the Cancer Research UK-funded PEACE study, which is shedding light on the final stages of life with cancer by analyzing tumor samples taken from autopsies with informed consent.[1]
Additional funding for this research was provided by Melanoma Research Alliance, The Royal Marsden Cancer Charity and Rosetrees Trust.