Study explores signature gut microbiome connection with immune checkpoint inhibitor response in advanced melanomas

Source: News Medical Life Sciences, March 2022

In a recent study published in Nature Medicine, a team of researchers from different countries performed a meta-analysis of real-world cross-cohorts and provided an association of the gut microbiome with immune checkpoint inhibitors (ICIs) response in patients with advanced melanomas.

The treatment of advanced melanomas has revolutionized with the advent of ICIs that target immune checkpoints such as programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). In patients treated with ICIs, gut microbiome composition has been associated with their clinical responses. However, limited data is available about the characteristics of specific gut microbiomes linked to the therapeutic benefits of ICIs in humans.