Stereotactic Radiation/Nivolumab in Patients With Melanoma Brain Metastases
Source: Cancer Therapy Advisor, December 2015
Stereotactic radiation to brain metastases in patients with metastatic melanoma receiving nivolumab appeared to prolong brain metastases control and overall survival, according to a study published in the Annals of Oncology.1
Investigators sought to determine the safety and outcomes in patients receiving anti PD-1 therapy and stereotactic radiation for the treatment of brain metastases. The study’s primary endpoint was neurotoxicity and secondary endpoints included brain metastases control and survival.
Investigators analyzed retrospective data from 2 prospective nivolumab protocols that included 160 patients with advanced, resected, and unresectable melanoma. Those with brain metastases were included if they were diagnosed and treated with stereotactic radiation within 6 months of receiving nivolumab.