Spanish researchers identify protein driving melanoma malignancy

Source: The Science Advisory Board, July 2022

August 3, 2022 — Several proteins are involved in the progression of melanoma, and one in particular, PDIA6, drives malignancy, researchers at the Centre for Genomic Regulation (CRG) in Barcelona found.

Using mice, the team found that melanoma cells with reduced levels of PDIA6 had an impaired ability to metastasize to the lung and that PDIA6 promoted melanoma malignancy by binding to RNA molecules inside the tumor’s cell (Nucleic Acids Research, July 15, 2022).

They used RNA fishing, also known as RNA interactome capture, to make this determination, which involves fishing out all messenger RNAs in a cell. They could then see which proteins were attached to the cells and which proteins were involved in the diversity of RNA-binding activities taking place inside the cells.

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