Sotigalimab/Pembrolizumab Combo Continues to Show Clinical Activity in Frontline Melanoma

Source: Onc Live, November 2022

The combination of sotigalimab (APX005M) and pembrolizumab (Keytruda) showed encouraging antitumor activity and was well tolerated in the frontline setting of patients with metastatic melanoma, according to updated phase 1/2 findings presented during the 2022 SITC Annual Meeting.

Sotigalimab is defined as a humanized IgG1 monoclonal antibody against human CD40.

As of October 28, 2022, the overall response rate (ORR) by RECIST 1.1 criteria among 32 patients on the study (NCT02706353) was 47%, which consisted of a 16% complete response rate and a 31% partial response rate; the stable disease rate was 22% and 31% of patients had progressive disease. The disease control rate was 69%.

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