Source: Medical Xpress, June 2025
Sex-based disparities in cancer are widely recognized, with men generally showing higher cancer incidence overall. Premenopausal women face heightened vulnerability to certain cancers, notably malignant melanoma, suggesting potential hormone-related pathways that are poorly understood and largely neglected in treatment strategies.
In the study, “Targeting GRPR for sex hormone-dependent cancer after loss of E-cadherin," published in Nature, researchers designed experiments to elucidate the role of estrogen and the adhesion molecule E-cadherin in cancer metastasis.