________________________________________________

DNA methylation subgroups in melanoma are associated with proliferative and immunological processes

Martin Lauss¹, Markus Ringnér¹, Anna Karlsson¹, Katja Harbst¹, Christian Busch²³,Jürgen Geisler²³⁴, Per Eystein Lønning²³⁵, Johan Staaf¹ and Göran Jönsson^1*

BMC Medical Genomics 2015, 8:73  doi:10.1186/s12920-015-0147-4

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Prickett et al.: Durable complete response in a patient with metastatic melanoma following adoptive transfer of autologous T cells recognizing 10 mutated tumor antigens.

Journal for ImmunoTherapy of Cancer 2015 3(Suppl 2):O4.

doi:10.1186/2051-1426-3-S2-O4

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Tissue resident memory T cells create genetically distinct immune microenvironments within melanoma metastasis

Kavita Dhodapkar1*, Noffar Bar1 , Chandra Sekhar Boddupalli1 , Krishna Kadaveru1 , Zifeng Mai1 , Yanhong Deng1 , Mario Sznol2 , Madhav Dhodapkar1

From 30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2015) National Harbor, MD, USA. 4-8 November 2015

Dhodapkar et al.

Journal for ImmunoTherapy of Cancer 2015, 3(Suppl 2):O15

http://www.immunotherapyofcancer.org/content/3/S2/O15

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The histone variant macroH2A suppresses melanoma progression through regulation of CDK8

Kapoor, A.; Goldberg, M.S.; CumberlandL.K.; Ratnakumar, K.; Segura, M.F.; Emanuel, P.O.; Menendez, C.; Vardabasso, S.; LeRoy, G.; Vidal, C.I.; Polsky, D.; Osman, I.; Garcia, B.A.; Hernando, E.; Bernstein, E. The histone variant macroH2A suppresses melanoma progression through regulation of CDK8. Nature, 2010, 468, (7327), 1105-1109.

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Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Peinado H, Ale?kovi? M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, Hergueta-Redondo M, Williams C, García-Santos G, Ghajar CM, Nitadori-Hoshino A, Hoffman C, Badal K, Garcia BA, Callahan MK, Yuan J, Martins VR, Skog J, Kaplan RN, Brady MS, Wolchok JD, Chapman PB, Kang Y, Bromberg J, Lyden D. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med. 2012, 18(6):883-91.

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The association between Parkinson’s disease and melanoma: a systematic review and meta-analysis

Pei Huang† , Xiao-Dong Yang† , Sheng-Di Chen* and Qin Xiao*

Translational Neurodegeneration (2015) 4:21

DOI 10.1186/s40035-015-0044-y

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Nivolumab plus ipilimumab in the treatment of advanced melanoma

Katy K. Tsai and Adil I. Daud*

Journal of Hematology & Oncology (2015) 8:123

DOI 10.1186/s13045-015-0219-0

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Current Biology 25, 2899-2914

TGF-b-Induced Transcription Sustains Amoeboid Melanoma Migration and Dissemination

Gaia Cantelli,1 Jose L. Orgaz,1 Irene Rodriguez-Hernandez,1 Panagiotis Karagiannis,2,3 Oscar Maiques,4 Xavier Matias-Guiu,4 Frank O. Nestle,2 Rosa M. Marti,5 Sophia N. Karagiannis,2 and Victoria Sanz-Moreno1, *

http://dx.doi.org/10.1016/j.cub.2015.09.054

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NATURE REVIEWS CLINICAL ONCOLOGY | RESEARCH HIGHLIGHT MELANOMA

Therapy combinations: celebrating more milestones

• Lisa Hutchinson

Nature Reviews Clinical Oncology (2015)

doi:10.1038/nrclinonc.2015.179

Published online 27 October 2015

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Cell Reports

New Functional Signatures for Understanding Melanoma Biology from Tumor Cell Lineage-Specific Analysis

Florian Rambow⁹,
Bastien Job⁹,
Valérie Petit,
Franck Gesbert,
Véronique Delmas,
Hannah Seberg,
Guillaume Meurice,
Eric Van Otterloo,
Philippe Dessen,
Caroline Robert,
Daniel Gautheret,
Robert A. Cornell,
Alain Sarasin,
Lionel Larue

DOI: http://dx.doi.org/10.1016/j.celrep.2015.09.037

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The Journal of Biological Chemistry

Post-translational Down-regulation of Melanoma Antigen-A11 (MAGE-A11) by Human p14-ARF Tumor Suppressor^*

1. John T. Minges^‡,
2. Gail Grossman^‡,
3. Ping Zhang^§, 
4. Tal Kafri^§,^¶,^?,**and
5. Elizabeth M. Wilson^‡,^¶,^‡‡1

First Published onSeptember 1, 2015, doi:10.1074/jbc.M115.663641October 9, 2015 The Journal of Biological Chemistry, 290, 25174-25187.

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Antioxidants can increase melanoma metastasis in mice

1. Kristell Le Gal¹,²,
2. Mohamed X. Ibrahim¹,³,
3. Clotilde Wiel¹,³,
4. Volkan I. Sayin²,⁴,
5. Murali K. Akula¹,³,
6. Christin Karlsson¹,³,
7. Martin G. Dalin¹,³,*,
8. Levent M. Akyürek²,
9. Per Lindahl²,⁴,
10. Jonas Nilsson¹,⁵and 
11. Martin O. Bergo¹,³,†

Science Translational Medicine  07 Oct 2015:
Vol. 7, Issue 308, pp. 308re8
DOI: 10.1126/scitranslmed.aad3740

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Evolving treatment options for melanoma brain metastases

Dr Thankamma

Ajithkumar, FRCR, Christine Parkinson, PhD, Kate Fife, MD, Pippa Corrie, PhD, Sarah Jefferies, PhD

DOI: http://dx.doi.org/10.1016/S1470-2045(15)00141-2

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Ribas, A. et al. Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial. Lancet Oncol. 16, 908–918 (2015)

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Zelenay, S. et al. Cyclooxygenase-dependent tumor growth through evasion of immunity. Celldoi:10.1016/j.cell.2015.08.015

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ONCOGENE

NFATc2 is an intrinsic regulator of melanoma dedifferentiation

V Perotti¹, P Baldassari¹, A Molla¹, C Vegetti¹, I Bersani¹, A Maurichi², M Santinami², A Anichini^1,3 and R Mortarini^1,3

Received 20 July 2015; Accepted 4 August 2015
Advance online publication 21 September 2015