Researchers Uncover Immune Environment of Rare Type of Melanoma

Source: Genetic Engineering & Biotechnology News, March 2022

Acral lentiginous melanoma is a rare type of skin cancer. It begins when the melanocytes in the skin grow out of control and form tumors. Little is known about the development of acral melanoma. However, a new study by Moffitt Cancer Center & Research Institute researchers reveals key differences in the cellular and molecular composition of acral melanoma compared to melanoma. Their findings may lead to new potential therapeutic targets.

Their findings are published in the journal Clinical Cancer Research in a paper titled, “Single cell characterization of the cellular landscape of acral melanoma identifies novel targets for immunotherapy,” and led by Keiran Smalley, PhD, professor and director of the Melanoma and Skin Cancers Center of Excellence at Moffitt Cancer Center, and Y. Ann Chen, PhD, senior member at Moffitt Cancer Center.