Researchers find combination can enhance ipilimumab immunotherapy
Source: Medical Press, June 2018
Using a targeted therapy to block a protein that suppresses T cell activity could improve cancer treatment with immune checkpoint inhibitors, researchers at The University of Texas MD Anderson Cancer Center report today in the Journal of Clinical Investigation.
The team showed that EZH2 is elevated in immune T cells in patients after treatment with ipilimumab, a drug that unleashes an immune response by blocking the activity of CTLA-4 on T cells, white blood cells that serve as the targeted warriors of the adaptive immune system.