Research in the news: Yale scientists identify gene that regulates the growth of melanoma

Source: YaleNews, February 2016

Yale Cancer Center researchers have identified a gene in melanoma that can dramatically affect the growth of the disease. The findings, published in the journal Cell Reports, provide new insight into how melanoma grows and identifies a new target for treatment of melanoma and other cancers.

Enzymes that chemically modify DNA, known as DNA methyltranferases, play critical roles in regulating gene expression during development, but their role in cancer formation is less clear. The new Yale study has uncovered a novel role for a specific DNA methyltransfearase enzyme — DNMT3B — in regulating melanoma growth.

Abnormally high expression of DNA methyltransferases is common in cancers, including melanoma. High expression of DNA methyltransferases can inappropriately switch genes off or on, which can contribute to tumor formation and growth. However, little is known about the specific growth-signaling pathways affected by DNA methyltransferase enzymes like DNMT3B. Yale researchers identified a specific cell-signaling pathway that is dependent on DNMT3B. They found that reducing DNMT3B delayed melanoma formation in mice by affecting mTORC2, a protein complex that is important for controlling cell growth, size, and survival.