Radiation Necrosis Common in Metastatic Melanoma With Intracranial Metastasis
Source: Oncology Nurse Advisor, April 2023
Radiation necrosis (RN) is common in patients who have undergone stereotactic radiation surgery (SRS) for the treatment of intracranial metastasis (ICM) from melanoma, with poor clinical outcomes, according to research recently published in Clinical Medicine Insights: Oncology.
Researchers conducted a retrospective review of adult patients with melanoma who either underwent SRS alone or a combination of SRS and whole-brain radiation therapy (WBRT) between 2013 and 2018. The collected data for analysis included demographics, tumor characteristics, radiation parameters, prior surgical and systemic treatments, and patient outcomes.
Nearly 92% of the patients received at least 1 systemic therapy prior to radiotherapy, but the researchers found that the type and number of treatments did not significantly vary in patients with radiation necrosis compared with those who do not develop it. Approximately 35% underwent resection prior to SRS.
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